TGD With Irbesartan - Hydrochlorothiazide Tablets Treat Hyperactivity In Patients With Essential Hypertension Clinical Efficacy And Casual Blood Pressure, Ambulatory Blood Pressure Comparative Evaluation

Objective:To observe the clinical curative effect and contrast evaluation of office blood pressure, ambulatory blood pressure monitoring on treatment of Yinxu-Yangkang type of primary hypertensives by Tianma Gouteng Yin or irbesartan-hydrochlorothiazide tablets; To explore the new ways on high blood pressure treatment and evaluation in combining traditional Chinese and western medicine. Methods:100cases of every group of Yinxu-Yangkang type of primary hypertension patients diagnosed by office blood pressure and24hours ambulatory blood pressure monitoring and eliminated the secondary hypertension or white coat hypertension were randomly selected to take medicines of Tianma gouten Yin(group1)150ml (tid), Irbesartan-hydrochlorothiazide tablets (group2,150/12.5mg qd) for4-5weeks respectively, Then, the clinical curative effect, changes in office blood pressure and24hours ambulatory blood pressure were compared. Results:The clinical symptoms of patients in the two groups were improved significantly and side effects were less; The curative effect at night in group TCM was not significant difference, blood pressure variability, nocturnal blood pressure drop rate and heart rate were not significant difference before and after treatment in the two groups;24-hour average blood pressure, daytime and nighttime mean blood pressure, daytime and nighttime blood pressure load values, had significant difference (p<0.01or p<0.05) before and after treatment in the two groups; The curative effect had significant difference (p<0.01or p<0.05) between two groups, the decompression range was less in group1than in group2in each period of the average blood pressure and blood pressure load; The office blood pressure is higher than the mean ambulatory blood pressure after treatment in the two groups.Conclusion:It had better improving efficacy of clinical symptoms and tolerability, and less side effects in treatment of hypertension patients byTianma gouten Yin or Irbesartan-hydrochlorothiazide tablets, but there are differences between the long-term adherence, these results are similar to the reported literature; And highlight the innovative research results of this study are:evaluation method different, the different antihypertensive effect.office blood pressure is easy to overestimate or underestimate the effect while the dynamic blood pressure index is more able to reflect the objective effect; The reasons and possiblities of lower antihypertension effect of Tianma gouten Yin than Irbesartan-hydrochlorothiazide tablets on ambulatory blood pressure may be follows:The evidence of dose-effect relation of evidence-based medicine is still short of; blood drug concentration is not easy to keep constant; or the bioavailability Possess obvious differences. So, Tianma gouten Yin improving hypertensives symptoms and the blood pressure drop is not necessarily proportional to. this is the new conclusion of dynamic blood pressure assessment. therefore, To explore some new evaluating ways of combining traditional Chinese and western medicine treatment of high blood pressure are necessary.