Neurosurgery Hospital Infection Pathogens Distribution And Drug Resistance Change

Objective:To investigate the positive rates and resistance rates of pathogenic bacterium fromnosocomial infection neurosurgical patients in our hospital during2008-2012in order toguide the clinical selection of antibiotics and to control nosocomial infection in theneurosurgical ward.Methods:To enter into a Microsoft SQL Server2000database and analyze the information ofneurosurgical nosocomial infection patients in our hospital during2008-2012, thepositive rates and drug-resistant rates of pathogenic bacterium were compared byEXCEL2003and SPSS16.0.Results:1. From2008to2012, the average of nosocomial infection in the neurosurgical wardwas8.14%. In the total820patients,834non-repetitive strains were isolated. The topfive pathogenic bacterium were Klebsiella pneumoniae, Pseudomonas aeruginosa,Acinetobacter baumannii, Staphylococcus aureus and Escherichia coli.2. The drug-resistances of Klebsiella pneumoniae, Pseudomonas aeruginosa andEscherichia coli had risen slightly in the five years. But there were no markeddifferences in statistics.3. The positive rate of Acinetobacter baumannii strains had increased during2008-2012.The drug-resistance rates to the most of antibiotics were high (＞50%), exceptcefoperazone/sulbactam. The drug-resistance had increased each year also.4. The positive rate of Staphyloeoecus strains had decreased each year prominently.But the positive ratio of methicillin-resistant Staphylococcus aureus (MRSA) in theStaphylococcus aureus had increased each year and the drug-resistances of MRSAwere severe.5. The drug-resistances of the top five pathogenic bacterium had increased in the fiveyears differently. Antibiotics, which had been frequently used, especially cephlosporins and quinofones, had become ineffectual. The cefoperazone/sulbaetam,imipenem and vancomycin remain effective in their own antimicrobial spectrum.Conclusion:1. The main pathogenic bacterium of neurosurgical nosocomial infections in ourhospital were gram negative bacilli in the five years from2008to2012.2. The positive rate of Acinetobacter baumannii and the positive ratio of MRSA hadincreased each year and the drug-resistances were severe. It is essential to strengthenthe monitoring to prevent and control the outbreak of nosocomial infections.3. All the top five pathogenic bacterium had shown the drug-resistance and it hadincreased. The use of antibiotics should be timely adjusted according to thesusceptibility results to reduce and delay the emergence of new drug-resistantstrains.