Alcohol Femoral Head Necrosis Disease Characteristics, Traditional Chinese Medicine Syndrome Correlation Analysis And Lipid Metabolism

Object:1By contrast with steroid-induced osteonecrosis, explore the pathogenesis of alcoholic osteonecrosis main features.2Collection of statistical analysis of alcoholic osteonecrosis of syndromes characterized by its standardized syndrome type to determine the alcoholic osteonecrosis of TCM criteria.3Explore the correlation between alcohol and lipid metabolism in the pathogenesis of osteonecrosis.Methods:Review statistics from January2012to March2014, admitted in Wangjing Hospital Chinese Academy of Traditional surgical treatment of bone and joint third, in line with Western osteonecrosis diagnostic criteria, patients identified through detailed interrogation of long-term history of heavy drinking, during the period of hospitalization perfect all the relevant checks by the doctor in charge (intermediate and above titles physician) through questionnaire form has been filled syndromes scale. Case of82cases,134hip, all patients were male, the youngest25years old, maximum77years, mean age45.4years old. Treated in the same period China Academy of Traditional Wangjing Hospital treatment of bone and joint three subjects, consistent with the diagnosis of osteonecrosis Western standards, through a detailed inquiry to determine the recent history of patients with steroid use, a total of90cases,156hip, male48cases, female42cases, the youngest18years old, the oldest75years old, the average age of40.7years old.Wangjing Hospital Medical Center in the same period of not suffering from osteonecrosis examination of adult males, did the relevant checks, a total of116cases of patients, the youngest19years old, maximum79years, mean age41.1years old. Using SPSS18.0statistical software to build a database of information on all input data be checked to make sure the information is accurate input information Information on all counts expressed as a percentage (%). For all syndromes cluster analysis, clustering method selection system clustering R cluster method, parameter selection farthest neighbors, clustering range of options pearson correlation. The various indicators of independent samples T-test for statistical analysis, for all ages5levels using single factor analysis of variance of quantitative data for statistical analysis.Results:Age groups will be divided into groups of young, middle-aged group and the older group (youth group between the ages of18-40, the middle-aged group between the ages of41-60years old age group is older than60years). Patients in the experimental group of82 cases, including25cases (30.5%) youth group, middle group of48cases (58.5%),9cases of elderly patients (11%). The mean age was45.44±11.19years old. Male82cases (100%), female0cases (0%). The incidence of14cases of left hip, right hip the incidence of16cases,52cases of double the incidence of hip. ARCO stage I phase0hips, Ⅱ of48hips, stage Ⅲ58hips, stage Ⅳ24hips. Hormones control group of90cases,156hips. Where youth group of54patients (60%),24cases (26.7%) of middle-aged group, older group of12patients (13.3%). The mean age was40.68±14.86years old. Male48cases (53.3%) and42females (46.7%). The incidence of11cases of left hip, right hip the incidence of13cases,66cases of double the incidence of hip. ARCO stage Ⅰ phase6hips, Ⅱ of71hips, Ⅲ of59hips, stage Ⅳ20hips. ARCO stage Ⅰ phase6hips, Ⅱ of71hips, Ⅲ of59hips, stage Ⅳ20hips. Through experimental alcoholic osteonecrosis and the healthy control group found, HDL, CHO, TG of P<0.05, statistically significant, and in the femoral head necrosis comparison of all ages can be found in the index HDL, young and middle-aged group comparison group, youth group than the middle-aged group, P>0.05; youth group and the elderly group compared to the young group is lower than the older group, P>0.05; middle age group and the older group compared to less than middle-aged group group, P>0.05. For indicators CHO, youth group and middle-aged group comparison, youth group than the middle-aged group, P>0.05; youth group and the older group compared youth group than the older group, P<0.05, P<0.01; aged comparison group and the older group, the middle-aged group than the older group, P<0.05, P<0.01. For indicators TG, youth group and middle-aged group comparison, youth group than the middle-aged group, P>0.05; youth group and the older group compared youth group than the older group, P>0.05; middle age group and older group In contrast, the middle-aged group than the older group P<0.05, P <0.01. For indicators LDL, youth group and middle-aged group comparison, youth group than the middle-aged group, P>0.05; youth group and the older group compared youth group than the older group, P<0.05, P<0.01; aged comparison group and the older group, the middle-aged group than the older group, P<0.05, P<0.01. Alcohol osteonecrosis of the same age group in comparison with the healthy control group lipid levels. Youth group, PHDL <0.05, PCHO<0.05, PTG<0.05, PLDL>0.05; middle-aged group, PHDL<0.05, PCHO>0.05, PTG<0.05, PLDL>0.05; older group, PHDL<0.05, PCHO<0.05, PTG<0.05, PLDL>0.05.Conclusion:1Alcohol osteonecrosis occurs in middle-aged men, often involving bilateral hip to double the incidence of hip mainly found when the disease has been mostly ARCO staging and Ⅲ and Ⅱ. 2Alcohol causes of morbidity due to osteonecrosis has its certain unique syndromes, which can be divided into phlegm, Meridian closed block, liver and kidney deficiency.3Alcohol osteonecrosis occurred with HDL, CHO, TG has some relevance, HDL abnormalities were no significant differences in the incidence of all ages, the elderly and the incidence of abnormal CHO more closely, but the onset of middle-aged and older people with TG abnormal close.