Effects Of NRG1 On Regulation Of Type A Extracellular Potassium Current In Cerebellar Granulosa Cells And Cellular Maturation In Rats

The Neuregulins are a family of four structurally-related proteins that are part of the EGF family of proteins. These proteins have been shown to have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including:cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses.Via incubation mouse cerebellum granule cells with EGF-like domain of NRG1, we observe NRG1significantly increase the transient outward K+currents also the protein quantity of KV4.2and KV4.3. The NRG/ErbB signaling pathway is the upstream pathway to mediate these functions. Moreover, NRG also promote the maturation of granule cells.