(Gd-DTPA) And WO _2.9 Nanoparticles Were Synthesized And Their Structures Were Characterized By X-ray Diffraction (XRD), X-ray Diffraction (XRD) CT Imaging And Photothermal Therapy

Magnetic Resonance Imaging(MRI) has been widely used in scientific andtechnological applications due to its visual and intuitional interface. In particular,biological imaging has been a rapidly growing field. Some of magnetic nanoparticleshave been used as magnetic resonance imaging contrast agents due to their uniqueproperties, such as large surface area and eiffcient contrasting effect. In our work,Uniform and extremely small-sized Fe304@D0PA(Gd-DTPA) nanoparticles weresynthesized，which engineered iron oxide based nanoparticles as enhanced Ti contrastagents. X-ray computed tomography (CT), another molecular imaging technologieswhich shows promise as a cost-effective means for detecting and characterizingsotf-tissue structures, skeletal abnormalities, also CT systems provide high-resolutionimages，arpid data acquisition, excellent sensitivity to skeletal tissue and goodsensitivity to sotf tissue, particularly when contrast-enhancing media are employed.To explore whether the X-ray diagnostic imaging contrast agents can achieve thepurpose of treatment, WO2.9nanopatricles were synthesized as W element has a largeX-ray absorption. On the other hand，WO2nto.9anoparticles have large amic defects,and strong near-infrared (NIR) localized surface plasmon resonances (LSPRs) havebeen observed. The studies include the following two parts:1.Synthesis of Fe304@D0PA(Gd-DTPA) nanoparticles and the studies of theMRI in HeLa cellsFeirdex (Fe3〇4) have been applied to the negative contrast agent (T2) on the medicinefor a long time, besides, the small size iron oxide nanoparticles are the potentialcandidate for Ti contrast agents because the nanoparticles can enhance the Ti effectby their large surface area with5unpaired electrons，suppress the T2effect by theirsmall magnetic moment, and have low toxicity. Moreover, Fe304@D0PA(Gd-DTPA)nanoparticles’ longitudinal relaxivity at0.5T (r!=10.0is2.7times largerth1an that of clinically used Tj-positive agent Gd-DTPA (ri=3_.7mM1s-)，Therefore,Fe304@D0PA(Gd-DTPA) nanoparticles were synthsised and lead to positiveenhancement in Ti-weighted MRI.2.Synthesis of tungsten oxide nanorods (WO2nd the.9) a studies of CT imagingand photothermal therapy of a tumor model in vivoThe blue solution of multi valence tungsten oxide under near-infrared (NIR)irradiation to produce well surface plasmon resonance, and because tungsten element having a high absorption coefifcient to the X-rays, we have designed and synthesizedWO2s as Xi.9nanorod-CT imagng and photothermal therapy agents. The fitted valuesof CT and solubility of the material is four times larger than that of iohexol under thesame conditions. On the other hand，60|ig/mL WO2.9nanorods irradiated at980nmlaser with a density of0.25W/2cm about10min, the temperature increase of theaqueous solution about19.8"C. In summary, The WO2lt.9nanorods for simuaneousused as X-ray CT imaging and NIR phototheimal therapy agents...