Study On The Reaction Of Allyl Trinity Amines With

Carbene as a common reactive intermediates in organic reactions,has been widely used in the field of organic synthesis. Because of special structure and activity,carbene was involved a variety of reactions type,such as with C-H, N-H, O-H insertion reactions, addition reactions of alkenes and alkynes, rearrangement reactions and so on.Dichlorocarbene is a well-known one carbon reagent. As one important member of the carbene family, it facilitated a number of transformations, such as Reimer-Tiemann reaction,cyclopropanations of alkenes, cyclopropanations of imines, etc. It plays a important role in the organic synthesis application. To date, the reaction of primary amines and secondary amimes with dichlorocarbene had been explored, respectively. The reaction of primary amines led to the formation of isocyanides.[4] And secondary amimes went through a N-formylation process and furnished amides in the end.However, to the best of our knowledge, there is no report on reactions of tertiary amines and dichlorocarbene. In this paper, we present a study on reactions of tertiary allylic amines and dichlorocarbene generated in situ from chloroform and potassium hydroxide. To explore the influence of different conditions on the reaction, perform an analysis to the prospective product and infer mechanism of the new reaction.