Study On Reduction And Kinetic Resolution Of Halogenated Aromatic Alcohols And Isoenzofuranone By Bimetallic Catalysis

1、One-Pot Enantioselective Synthesis of chiral Aromatic Halohydrins via Au/Ru CatalysisAromatic Halohydrins was achieved via Au/Ru Catalysis using IPrAuNTf₂ and RuCl[（S,S）-Ts DPEN]（mesitylene）（TsDPEN =N-（tosyl）-1,2-diphenylethylenediamine）as catalysts and formic acid/triethylamine（5:2） as hydrogen source in DCE, afforded the desired products in good yields（up to 97%） and high enantiomeric excesses（up to99%）.2、Asymmetric Transfer Hydrgenation of isobenzofuran-1（3H）-ones via Dynamic Kinetic ResolutionWe synthesized a series of isobenzofuran-1（3H）-ones, which underwent symmetric reduction by using HCOOH:Et₃N = 5:2 system as the hydrogen source and（S,S）-T_s DPEN based Ru（II） catalyst, providing the corresponding chiral hydroxyphthalides in good yields（up to 98%） with diastereomeric ratio（up to 90/10）and high enantiomeric excesses（>99%）.