Preparation Of P - Methoxycinnamic Acid Isooctyl Microcapsules By Complex Coagulation Method

This paper was to investigated the preparation technology of microcapsules systematacially. A complex coacervation method was established, which used glatin and sodium polyphosphate as wall material, octyl methoxycinnamate as core material. Utilized the encapsulation efficiency and release amount as the indicators to study the oil loading amount, pH at complex coacervation and the condition of crosslinking on the property of microcapsules.Through SEM to investigated and compared the microstructure of microcapsules prepared with different wall materials, gelatin and sodium polyphosphate were selected as wall materials.Response surface methodology was employed to optimize the technology, and a polynomial regression model equation was generated. The effects of three variables, oil loading amount, pH at complex coacervation, and amount of cross-linking agent, on encapsulation efficiency were studied. The best preparation technology conditions: the oil loading amount was 50%, the pH and temperature of complex coacervation was 4.31 and 50 ℃, respectively, 3.31 mM/g G glutaraldehyde was crosslinking 1 h at 60 ℃. The optimization method enabled to predict the response variable value within the experimental range with high fit indicator and good agreement.The microcapsules under the optimized conditions appeared spherical in shape with smooth non-porous surface and no tendency to aggregatio, with a narrower particle size distribution and uniform particle size. The average particle size of microcapsules was 3.376 μm, while the encapsulation efficiency was 92.41%. Depending on the results of release, transdermal permeation and absorption efficiency experiment, it concluded microcapsules had achieved lowing release rate, decreasing transdermal permeation of OMC and its photodegradation product and improving effectiveness of UV absorption.