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The Research Of Direct Arylation Reaction Catalyzed By Transition Metal Palladium Compounds

Posted on:2016-09-14Degree:MasterType:Thesis
Country:ChinaCandidate:M D WangFull Text:PDF
GTID:2271330461493490Subject:Organic Chemistry
Abstract/Summary:PDF Full Text Request
Transition metal catalyzed C-C bond formation reaction had a significant impact on the organic chemical industry, which has been widely used in various fields of organic synthesis. In recent years, a series of C-H bond directly activation reactions, compared to traditional transition metal catalysis, have advantages of without preactivations and directing groups, thus more and more organic chemists have been paid attention to these reactions. Palladium is the most widely used transition metals that plenty of reactions was catalyzed by palladium compounds. This paper is divided into two parts, mainly researching for two kinds of palladium catalyzed C-H bond direct arylation.In part one:a N-heterocyclic carbene palladium compound was synthesized and used this in the direct arylation between electron deficient arenes containing fluorine and aryl iodides. This reaction has the following advantages:all the reagents used are common, and the load of the palladium catalyst was low (only 3 mol%). In addition, the mild condition combined with the favorable meta-selectivity give a highlight to this reaction.In part two:we used palladium acetate as catalyst to preliminarily establish an effective way for the direct arylation of ferrocenes and aryl bromide. Compared with the traditional method of ferrocene arylation reaction, the brightpoint of this method was the fact that the direct arylation of this electron-poor aromatic compounds can be conveniently achieved without directing groups. The catalyst was cheap and commercially available, which provides an effective means for coupling of metallocene and arenes.
Keywords/Search Tags:C-H activation, direct arylation, palladium catalyzed, N-heterocyclic carbenes
PDF Full Text Request
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