Research Of Ibuprofen Controlling And Releasing Based On Two Kinds Of Synthesis Of Mesoporous Silica Materials

Ibuprofen is one of the world generally accepted non-steroidal antipyretic analgesics, and controlled release system can maximize its pharmacological activity in the human body, and to reduce dosing dose. Early in the synthesis of mesoporous materials channel is irregular, uneven distribution of pore diameter, make its application in drug controlled release has been greatly restricted. It has more holes and particle shape features of the synthetic MCM-41 mesoporous silica material with gel and sol method. And then through different external stimulations to affect the surface physical and chemical properties to control the functional molecules of silica pores open and close, thus achieve the goal of control release drug molecules in the hole. This paper prepared two kinds of mesoporous silica materials include MCM-41 and MCM-41-Epoxy with the method of gel and sol and adding organic expanding agent. And then do comparative study of ibuprofen of mesoporous silica with the carrier of the synthetic mesoporous silica. The concrete research content is as follows.(1) Synthesis and characterization of mesoporous silica materials. it produced chemical reaction with template CTAB(cetyl trimethyl ammonium bromide) and TEOS(silicon source species) in alkaline conditions, and then added 1,3,5- three toluene(expanding) preparation of larger pore size of mesoporous silica and used acid pickling method to remove the template after the reaction. On the basis, then do epoxy group functionalization of the prepared MCM-41. It prepared epoxy group functionalization of MCM-41-Epoxy materials with anhydrous toluene as reaction medium, MCM-41 reacted with silane coupling agent KH560(γ-glycidoxy propyl trimethoxy silane) under high temperature condition. It finally did a series of characterization including infrared and scanning electron microscopy, X-ray powder diffraction(XRD), nitrogen adsorption and stripping. The results showed that characteristic peak of epoxy group is around 910 cm-1, and the material specific surface area(SBET), entrance V/( cm3.g-1), the pore size(D/nm) and XRD diffraction peak of MCM-41 were greater than MCM-41-Epoxy.(2) Research of ibuprofen loading and its controlling and releasing. It put the two kinds of material in a high concentration of ibuprofen and adsorption in full, until the ultraviolet absorption absorbance changes no longer. And then calculate the respectively load rate for ibuprofen of the two kinds of mesoporous materials with MCM-41 with 18.92% and MCM-41-Epoxy with 27.36%. Research of the ibuprofen release rate of MCM-41-Epoxy-IBU through the simulation of two kinds of human body fluid p H. And construct a releasing system with PBS buffer solution PH 7.4 as stress. As a conclusion, MCM-41 release fast and was saturated around 9h with releasing quantity more than 80% and MCm-41-Epoxy release slow and the releasing quantity was about 65% after 24 h.