Enantioseparation Of Amlodipine Besylate Via Molecular Imprinted Composite Hollow Fibers

Based on the urgent need of homochiral drug,yet the quantity of pure chiral drugs under producing is rare. So its significant to find a resolution method for certain, or even certain types of chiral drugs can be applied to large-scale. With the success of membrane technology has been impressively demonstrated for large scale industrial applications,and molecular imprinting technology has been relatively mature in the separation and detection applications. To this end, this paper made antihypertensive drug- amlodipine besylate as separation object, combined the molecular imprinting and membrane separation technology, applied a self-assembly component to separation. The main work of this thesis is summarized as follows:1. A kind of molecularly imprinted composite PVDF hollow fiber with high capacity of levamlodipine besylate was obtained. The optimum conditions for the synthesis of polymer membranes were investigated. On account of the memorial hole for levamlodipine besylate of the second imprinted membranes, its maximum adsorption factor reached 1.62 and adsorbing capacity value was 0.69 μmol/g. Compared with non-imprinted and blank membrane, the adsorption process for template molecule was nonspecific. Also, SEM result indicated that the membrane surface was coated with a layer of dense polymer.2. Assembled the imprinted composite PVDF hollow fiber into the independently developed membrane modules to conduct separation. And optimized affect conditions of the separation system such as cross-flow velocity of influent and other solvent circumstance, in order to achieve large-scale separation. Also, a separation flow mathematical model was established, and through the theoretical calculation of infer: to get the optical purity of the target over 90%, need this kind of component 130 cm only. With new progresses appear in the high separation of chiral drugs, our work would probablely provide the basis support for the industrial enantioseparation of amlodipine besylate.3. Another levamlodipine besylate molecularly imprinted composite PVDF hollow fiber was synthesized by using the method of controllable surface imprinting before self-assembly them to the independently design and manufacture component. Here we specially introduced chiral resolution additive for higher throughput. For this purpose, suitable type of chiral selectors and different liquid phase, concentration, solution pH value and so on factors was investigate to reach the best separation. We found out it could separate target drug effective when d-tartaric acid was added to inner side and SBE-β-CD to outside phase simultaneously, followed theoretical calculation of infer showed that just 90 cm length of such component was required to get levamlodipine besylate with purity of 90%. Meanwhile due to the additives’ nontoxic to human body, there was no need for further separation and purification.