Construction And Application Of Molecularly Imprinted Polymer Arrays Based Sensor

With the development and integration of materials science, biological chemistry and polymer chemistry, a new technology, molecular imprinting technique, has emerged. Molecularly imprinted polymers(MIPs) are tailor-made biomimetic materials that are capable of specific recognition towards target molecules. The specific recognition property, high stability, easy preparation and low cost of these MIPs make them extremely attractive as sensing materials in biomimetic sensors. In situ electropolymerization has been utilized to prepare MIP films easily. However, due to the imprinted sites are embedded in the MIP films, restricted mobility is still suffered, thus affect the performance of the MIP-based sonser. This dissertation consists of four chapters as follow:In chapter one, a brief introduction of molecular imprinting technology is given. The topics discussed include the history, principle, synthesis methods and applications of MIT and MIPs. Based on these, the research objective and experimental plan of this dissertation are also presented.In chapter two, vertically aligned ZnO nanorods were grown on ITO/PET film by one step seed-free electrodeposition and used as high-surface scaffolds for 3-D polypyrrole arrays deposition. These polypyrrole arrays were prepared by in situ electropolymerization of pyrrole onto ZnO nanorods. These polypyrrole arrays are independent of each other. In addtion, these polypyrrole arrays are coated by a layer of tiny nanoparticles.In chapter three, three-dimensional molecularly imprinted polypyrrole arrays were prepared by using epinephrine as the template on the basis of chapter two. Due to the imprinted sites are located at the surface, as well as high specific surface area, these MIP arrays have good site accessibility to template. These MIP arrays were used them as sensing material and integrated into an electrochemical workstation to fabricate a MIP arrays based electrochemical sensor. The obtained MIP arrays based electrochemical sensor showed high sensitivity and good selectivity for template.