Total Synthesis Of Natural Products Alsmaphorazine Derivatives

The thesis aims at the studies on the total synthesis of the natural product Alsmaphorazine E which are extracted from nature. We use organic chemical knowledge about synthesis, combining the latest scientific research theory and the use of identification and improved means to accomplish the goal. This paper mainly expounds our research ideas and the main problems encountered in the course of the study and its solution. The article is divided into two parts:In the first part, we introduce the background of Alsmaphorazine E and their family menbers, including how they are extracted and separated and how their absolute configuration are determinated, also introduces some possible biosynthetic pathway to synthesis them.It’s a challenge to synthesis the natural products because their structure are so complex.Therefore, it’s important to explor the molecular total synthesis. And the series of molecularcontent in nature is low, difficult separation, therefore completing the total synthesis of Alsmaphorazine E, identification of its biological activity and related derivatives, have important significance to the related disciplines. Therefore we had a strong interest in this subject.In the second part, we will focus on the work of total synthesis including inverse synthetic analysis, synthesis progress and plans for future work.