Synthesis Of A New Redox-responsive Nanogel Based On Poly(ionic Liquid)s And Its Application In Controlled Drug Release

The stimuli-responsive polymer is a kind of macromolecular structure or status can change greatly affect their physical and chemical properties, resulting in an ideal material features, such macromolecular systems mainly by accepting such as temperature, light, p H, redox molecules and other external Transmigration stimulus signal to achieve its "intelligent" behavior. The results show that in recent years, irritant responsive polymers can be added without requiring additional auxiliary condition, we can use the differences between the body’s internal environment to achieve controlled drug release control system, is a very good drug contr ol system. And, in many areas it has important applications, such as nano-catalysis, clinical medicine, chemical sensing and biotechnology fields.In the previous study, we found that the introduction of hydrogen in ionic liquid based on poly nanogels interaction, you can get new stimuli-responsive polymer material having a reversible temperature-responsive and p H-responsive. Based on this, by the ionic liquid monomer and crosslinking agent contains a disulfide bond crosslinked copolymer in selective solvents A novel redox-responsive nanoparticles. Different reaction conditions of the polymer, the particle size distribution, surface morphology were characterized in detail and determination; investigate its controlled release properties of the model drug rhodamine B’s. The main contents include the following:1, The crosslinking agent contains disulfide bonds were prepared-(2-ethyl methacrylate) disulfide(DSDMA); prepared with different linking ionic liquid: 1,4-butyl-3,3 ’- di-1-vinylimidazole bromide([BIM-4C] Br), 1,6- hexyl-3,3’-bromo-1-vinyl imidazole bromide([BIM-6C] Br), by 1HNMR, 13 CNMR, IR, MS and their structures were characterized in detail. With azobisisobutyronitrile(AIBN) as initiator, in selective solvents by radical polymerization step synthesis of nanoparticles based on poly ionic liquids. Adjusting the proportion of monomers and crosslinkers investigated its effect on nanoparticle formation, and by dynamic light scattering(DLS) was measured for its particle size, ξ- potential. Using FTIR, TG, SEM and other means to characterize the morphology of the nano-ion structure, performance, and so on. Also by adding dithiothreitol(DTT) and benzoyl peroxide(BPO) made its determination of the redox-responsive, and Rhodamine B(RB) as a model drug, the drug controlled release of nano ions were the inspection.2. Preparation of the 4-vinylbenzyl chloride, triphenyl phosphonium ionic liquids(PILPh), and uses the previous section of two disulfide-containing-(2-ethyl methacrylate) disulfide(DSDMA) and ethylene glycol dimethacrylate(EGDMA) as cross-linking agent to azobisisobutyronitrile(AIBN) as initiator, in selective solvents by radical polymerization step synthesis of nanoparticles based on poly ionic liquids. Adjusting the ratio of monomer and crosslinker, examine its effect on the formation of nanoparticles, and by dynamic light scattering(DLS) was measured for its particle size, ξ- potential. Using FTIR, TG, SEM and other means to characterize the morphology of the nano-ion structure, performance, and so on. Also by adding dithiothreitol(DTT) and benzoyl peroxide(BPO) made its determination of the redox-responsive, and Rhodamine B(RB) as a model drug, the drug controlled release of nano ions were the inspection.3. The preparation of the pillar[5]arene the precursor of hydroquinone bis-(2-bromine ethyl) ether, on the basis of the synthetic completely symmetrical column successful pillar[5]arene, and it ends with reactive group.