Synthesis And Catalysis In Organic Reaction Of Ceria Nanoparticles With Different Morphologies

There has recently been considerable interest in the synthesis and use of nanoparticles in industrial production. However, their application in organocatalysis remains to be further research and development. In this thesis, four new nano CeO2 with different morphologys were synthesized and used as efficient catalysts in organic synthesis for the first time.This dissertation is divided into five chapters:Chapter one introduced the base of selection of this subject, the significance, the domestic and foreign research of nanomaterials, the original points and the research techniques, especially in the properties of nano materials, preparation and catalysis.In chapter two, four new nano CeO2 with morphologys of porous, granular, spindle shaped and linear respectively were synthesized firstly by template-free hydrothermal method, while CTAB, urea and ammonium carbonate were used as morphology controlling agent. Nano CeO2 generally possesses a high specific surface area and are chemically stable that display their potential catalytic activity and application in organic synthesis.In chapter three, four new morphologies of nano CeO2 were firstly used as efficient and recyclable heterogeneous catalyst for the Ugi-Smiles coupling reaction of an aldehyde, malononitrile, isocyanide and unactivated heterocyclic thiophenol in high yields with high atom economy. The bioactivities of the products have been studied and the study shows that: Both of the two series products have high antibacterial activity. There is 7 products has specific inhibitory activity of Staphylococcus.aureus, which shows the tremendous development potential.In chapter four, porous CeO2 nanorods were firstly used as an efficient and recyclable heterogeneous catalyst to promote the preparation of tetrasubstituted imidazoles derivatives. The bioactivities of the products have been studied and obtained a nice effect.In chapter five, porous CeO2 nanorods were firstly used as an efficient and recyclable heterogeneous catalyst to synthesize the quinoxaline derivatives via the condensation of benzil derivatives and diamine derivatives in EtOH at room temperature with high yield. The bioactivities of the products have been studied and accessed to good results, which provides a basis for the further structural modification and looking for high active of such compounds.The remarkable advantages of the catalyst in this paper are excellent yields, high atom economy, wide application range of substrates and can be used repeatedly, which expands the application of nano oxides in organic synthesis and provides a new way for the synthesis of the compounds.The structures of the products were confirmed by 1H NMR, 13 CNMR, IR and HRMS.