Synthesis And Methodological Study On Ring - Forming Reaction Of 3 - Substituted Isatin Derivatives

This thesis is concered with 3-substutide isdine isdine and its derivatives cyclization reaction with conjugated diene and salicylic aldehyde. It mainly consists of the following three parts:Part one Introduces the synthesis of isatin and its derivatives and their participation in the catalytic asymmetric synthesis and tandom reaction both at home and abroad, give an outline of meaning,method and innovation point to this research.Part two C-3 position of isatin derivative with diene via [4+3] cycloaddition. In this part,we first reported the synthesis of heterocyclic derivate on C-3 position of isatin,to try many different kinds of condition and dienes, we found that Mg(Cl O4)2 in DCM is the most efficient way to form the seven number skeleton. Using 1H-NMR13C-NMR and X-ray crystal structure analysis to conform the structure of the product.Part three The tandem reaction of Isatin derivatives with salicyl aldehyde. In this part,we give a short introduce about salicyl aldehyde and salicylic imines withα,β-unsaturated compounds. Our team first use C-3 position unsaturated isatin derivatives with salicyl aldehyde via a tandem Michael-Aldol reaction successful and effective build a spiro-[5,6] benzopyrrole skeleton. The product was verified by1H-NMR13C-NMR and X-ray crystal structure analysis.