Preparation And Performance Of Cyclodextrin-modified Magnetic Nanoparticles And Nanographene

Magnetic nanoparticles(MNPs) have been widely applied in the fields of chemical separations, targeted drug release as well as catalysis due to their excellent characteristics of superparamagnetism, large specific surface area, excellent biocompatibility and low toxicity. b-Cyclodextrin(b-CD) has unique structure of hydrophilic outer surface and hydrophobic interior cavity, which can selectively include numerous organic and inorganic small molecules by forming host/guest inclusion compounds, and have been used in adsorption removal of pollutants, as hydrophobic drug carriers and biosensors and so on. Graphene, atom monolayer graphite, is one excellent adsorbent material owing to its huge specific area, abundant functional groups on its surface, low price as well as easy large-scale production. Making some modification on MNPs or graphene nanosheets using b-CD and smart polymer materials, the stability of the obtianed magnetic nanomaterials certainly will be dramatically improved, and the obtained composites will have multifunctionalities. In the dissertation, a serial of multifuncational magnetic nanomaterials were prepared via decorating MNPs and MNPs-loaded graphene nanosheets using b-CD and poly(N-isopropylacrylamide)(PNIPAM). And their application potentials in targeted drug controlled delivery and bioseparations were also investigated. The detailed contents as follows:1. Magnetic Fe3O4 colloidal nanocrystal clusters(Fe3O4 CNCs) were firstly prepared via modified solvothermal method, and then b-CD monomolecular layer decorated MNPs(Fe3O4@GLY-CD) were syntheisized using(3-glycidyloxypropyl) trimethoxysilane(GLY) as an intermediate linker. The loading and release properties of the synthesized Fe3O4@GLY-CD for a hydrophobic molecule 8-anilino-1-naphthalenesulfonic acid ammonium salt(ANS) were also investigated.2. β-CD polymer brushes decorated Fe3O4 CNCs(Fe3O4@PG-CD) were fabricated by a combination of surface-initiated atom transfer radical polymerization(SI-ATRP) and ring-opening reaction of epoxy groups using glycidyl methacrylate(GMA) as a monomer. The loading and delivery performance of the as-synthesized Fe3O4@PG-CD for a hydrophobic anticancer drug 5-fluorouracil(5-FU) was also investigated, and the release machenism was primarily discussed.3. Thermosensitive β-CD polymer brushes decorated Fe3O4 CNCs(Fe3O4@PNG-CD) were fabricated by a combination of SI-ATRP and ring-opening reaction of epoxy groups using GMA and NIPAM as monomers. The thermosensitive adsorption/decomplexation properties and delivery performance of the as-synthesized Fe3O4@PNG-CD for ANSmolecules were also investigated.4. Thermosensitive β-CD polymer brushes decorated magnetic graphene(Fe3O4@GO@PNG-CD) were prepared by a combination of SI-ATRP and ring-opening reaction of epoxy groups using GMA and NIPAM as monomers, graphene as the grafted substance. The thermosensitive adsorption/decomplexation performance of the as-synthesized Fe3O4@GO@PNG-CD for L,D-Trptophan(L,D-Trp) was also investigated.