Research On Water Extraction Technology And Taste Masking Of Jianweixiaoshi Tablet

With the continuous improvement of living standards, more and more people begin to focus on diet problems. Dyspepsia is one of the serious problems and jianweixiaoshi tablet can cure incoordination between the spleen and the stomach, dyspepsia and anorexia. However, Chinese herbal medicine taste is complex and bitterness is one of the most significant tastes. Therefore, three common taste masking methods including flavoring agent method, fluidized bed microencapsulation method and including method were used in this research, for providing a series of reference for taste masking of Chinese herbal medicine.At first, the optimum condition of extraction procedures was studied. It was found that soaking time was half an hour, extracted with water (10 times of the materials) was 2 times and two hours of each time. The highest dry paste yield could be obtained using the leaching process conditions.In the flavoring agent method, aspartame stevioside mannitol and citric acid and unpleasant taste agent were mainly added. It was found that 3% amount of aspartame could cover bitterness and taste good. Stevioside also could cover bitterness, but adding threshold was narrow because adding too much would have bad taste of hemp tongue. Mannitol sweetness was too low with little obvious effect on taste masking. Adding of 1% citric acid had certain sour to cover bitter taste with a cool and refreshing feeling.In the microencapsulation method, the best granulating conditions was obtained by granulating coating experiment. It was found that atomizing pressure was 0.15 MPa, flow rate was 7.5mL/min and inlet air temperature was 80℃. Moreover, bottom spray coating with 10% concentration of gelatin as coating liquid, better taste masking effect was gotten while weight gain rate was 80%.In the including method, the highest inclusion rate was obtained using berberine hydrochloride as drug model. It was found that by the grinding method the highest inclusion rate was gotten, with β-cyclodextrin and berberine hydrochloride of the ratio 3:1, inclusion time of 20 min, adding water of 3 times of the materials. Inclusion compound was identified by SEM and IR spectrum. Jianweixiaoshi tablet was included under optimum inclusion conditions and also was identified by SEM and IR spectrum.Finally, after taste masking quality standard identification experiment of the drug was studied. It was found that jianweixiaoshi tablet had the effective components of radix pseudostellariae by the thin layer chromatography. Using HPLC method the content of hesperidin in jianweixiaoshi tablet after taste masking was 0.24 mg/tablet. It conformed to the provisions of the pharmacopoeia which was more than 0.2 mg/tablet required.