Preparation And Application Of Polymer Coated Gold Nanorod Nanocomposite

Recently metallic nanoparticles and semiconducting polymer nanoparticles have aroused considerable attention because of their excellent physical and chemical properties. They have been extensively applied in various fields, such as biomedicine, material science, environmental energy and so on. Despite the nanoparticles synthesis and application are still the hotspot of research, nowadays, researchers are attempting to integrate different nanomaterials attaining different properties into a nanocomposite system, which consequently will produce a nanocomposite nanoparticle possess several functions simultaneously. So we can further develop the application of the nanocomposite materials in various fields. This paper focused on the preparation of nanocomposite material, and studies its application in the field of optical imaging. The main research content of this paper is as follows:In chapter 1, we briefly summarized the optical property of nobel nanoparticles, the synthesis and application of gold nanorods, the research background of core-shell structure of metal nanomaterials and semiconducting polymer nanoparticles, as well as the optical imaging technique based on nanoparticles.In chapter 2, a three-layer core-shell plasmonic nanorods: silica-silver-gold nanorod(SSGNR) was successfully prepared. Then semiconducting polymer(poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-co-(1,4-benzo(2,1’,3)-thiadiazole)], PFBT) was coated onto the surface of SSGNR. In addition, we optimized the thickness of silver and silica shell of SSGNR in order to study how the fluorescence performance of PFBT changes. According to the spectroscopic characterizations, the fluorescence intensity of PFBT could be enhanced around two fold when assembling onto the suitable SSGNR surface compared with the fluorescence intensity of regular PFBT polymer dots without the metal core.In chapter 3, we select the PFBT-SSGNR nanoparticle with excellent fluorescence performance synthesized in last chapter to analyze its optical properties at single particle level. In order to examine its application prospect in the field of optical imaging, optical microscope was used to study the scattering properties and fluorescent stability of this nanocomposite.In chapter 4, a dark-field and fluorescence dual-modal microscopy imaging system was built to study the application capacity of this PFBT-SSGNR nanoparticles in tumour cell imaging and single particle tracking at living cell level.