Fabrication Of Microchannel Reactor And Application Of Research

Microreaction technology is one of the new area for the development of chemical engineering development, attracting the attention of the researchers in lab and chemical industry all around the world.Microreactor technology afforded chemical reaction many unique advantages including the strengthening the heat transfer, mass transfer. Compared with the conventional reactors, the reaction conditions could be controlled more accurately and the product quality could be better by microreactor. Furthermore the synthesis processes could be faster, safer and cheaper, the yield could be higher and the selectivity could be better. Microreactor not only can be an useful tool in laboratory, but also can be used in mass production technology. By well organized the microreactor units in a proper way, the amplification output could be achieved easier.In this thesis the microreactor, including its classification and features such as high efficient heat and mass transfer ability were introduced. The application of microreactor in organic reactions were summerized, such as the nitration, oxidation, acylation reaction and pharmaceutical synthesis et al and its advantage in industrial application.Four aspects, including the fluid conveying devices, fluid pipeline and connecting sealing parts, fluid mixing components, selection of reactor were summerized. A brief overview about the assembly of the system and applicability of the system for those reactions containing different chemicals. A set of microchannel reactor system device was settled which was suitable for the acylation of aromatic derivatives.The microchannel reactors have been applied in the synthesis of acylferrocene through Friedel-Crafts acylation reactions of ferrocene using acyl chlorides as acylating agents, aluminium chloride anhydrous as catalyst and dichloromethane as solvent. The crude products were characterized qualitatively and quantitatively by HPLC after simple post-processing. Different reaction conditions were carefully selected to perform the reactions, including selection of microchannel pipes, temperatures, volume flow rates, reaction times, reactant ratios, to optimize the preparation processes. The synthesis of (4-chlorobutyroyl)ferrocene, octanoyl-ferrocene, hexanoylferrocene, butanoylferrocene in the microchannel reactors were carefully studied. The synthesis method with the highest yields of acylferrocene were determined and the possibility of industrialization were discussed.