Synthsis Of Some Fused N-Heterocycles Via Copper-Catalyzed Tandem Reaction

catalytic tandem reaction is a convenient and effective method for the construction of compound with considerale complexity. Since copper catalysis has its unique advantages in synthsis of heterocyclic compounds, it has been drawn the concerns in organic chemistry. Wherein, the copper-catalyzed tandem reaction is one of the hot spots.The dissertation focused on the synthesis of certain fused N-heterocycles via copper-catalyzed tandem reactions.Chapter 1 briefly reviews the study on copper-catalyzed C-N/C-S coupling reaction and its tandem reactions for the synthesis of heterocycles.Chapter 2 describes the copper-catalyzed tandem coupling/double cyclization reactions of 2-alkynyl-6-iodoanilines and o-bromobenzenethiols for the synthesis of pyrrolo[3,2,1-kl]phenothiazines using the catalytic system of Cul/L-proline/cesium carbonate. A variety of functional groups were compatible under these conditions.The procedures are simple, and the yields are moderate to good.Chaper 3 describes the tandem reaction of N-propargylanilines and copper cyanide for the synthesis imidazo[2,1-α]isoindolinone promoted by organic base. We optimized The reaction conditions have been optimized. The reaction conditions are green and simple with good atomic economy.