Organocatalytic Synthesis Of Spirocyclic Oxindole Derivatives Via [3+2] Annulation And Asymmetric Photocatalysis

This thesis is divided into three parts, comprising two contents.The first chapter mainly introduces the development of asymmetric synthesis of spirooxindole derivatives. It is a kind of very useful organic compound. These compounds have played important roles in biological and medicinal chemistry. The methods of synthesis the spirocyclic have been promoted recent years. There are many ways to synthesis spiro three-membered fused or spiro five-membered rings oxindoles. But to constructed spiro four-membered rings and spiro-cyclohexanone oxindoles are rare. Asymmetric organocatalytic construction of spirocyclic oxindoles are also challenging.The second chapter mostly introduced a [3 + 2] annulation of Morita-Baylis-Hillman carbonatas with isothiocyanates to synthesis of spirocyclic oxindole dihydrothiophenes. The Morita-Baylis-Hillman(MBH) carbonates, which are derived from isatins and act as very useful synthons. Most of all, MBH adducts, being very useful 1,3-dipole precursors,have been used to synthesize many heterocyclic architectures with a variety of electron-deficient olefins by nucleophilic tertiary-amine catalysis.The last chapter introduced asymmetric photocatalysis.In recent year, photoredox has drawed many attention, but for asymmetric photoredox are less. Under visible light activation, the control of enantioselective should combine chiral matrix or chiral source. therefore, the research of asymmetric photocatalysis that to design new photosensitizer and new phototrdox catalyst.