Studies On The Process Conditions Of Pentosan Sulfates From Corn Straw

Corn straw is a type of renewable biomass. However, there are some well-documented problems related to environmental pollution due to the insufficient use of corn straw. Pentosan, with a variety of biological activities, such as immune regulation,anti-tumor, anti-oxidation, ate, is a kind of hemicelluloses, which is one of the most wide spread polysaccharides in nature. Especially its sulfuric acid attracts more and more attention for a better water solubility and broader biological activity.Thrombus are hereditary, recurrently and increasingly younger, it cause serious harm to human health. For decades, heparin is the drug of choice to treatment of thrombosis disease. Further, due to the continuous world-wide increase in the use of heparin, the natural sources may not be sufficient to meet the need in future. Therefore, an important field of research is the development of effective alternatives to substitute for heparin. One possibility is sulfated polysaccharides chemically related to heparin. After the sulfated modification, pentosan has also shown high blood compatibility due to the structural similarity to that of heparin. Consequently, pentosan sulfates having a similar or even improved action profile represent a promising filed of research.The isolation of corn straw pentosan, the sulfated reaction condition of pentosan were studied in this paper. Pentosan were separated from corn straws by alkali extraction method.Comparing the performance of C5H5N·SO3/DMF、C5H5N·SO3/C5H5N、C5H5N·SO3/C5H5N、H2SO4 and(NaHSO3)3N in reaction of prepare pentosan sulfates, which were the candidate sulfonated systems, along with their productivities and sulfuric substituting degrees, we determined that(NaHSO3)3N is the most suitable one for pentosan. By(NaHSO3)3N method, the pentosan could be sulfated successfully. The optimum conditions for sulfation of pentosan were 1:40 of volume ratio of pentosan to(NaHSO3)3N, 50 ℃ of reaction temperature, 5 h of reaction time, 9 of reaction pH. Under these conditions, the degree of substitution of pentosan sulfates was up to 1.714.