The Synthesis Of Smart Response-type Amphiphilic Molecules And The Research On The Properties Of Their Self-assemblies

The rigid-flexible amphiphilic molecules consisted of hydrophobic block and hydrophilic block can self assemble into nano-aggregates. Currently, these nanoaggregates have exhibited a wide application fields, including drug carrier and cell engineering. Here, we designed V-shaped and dumbbell-shaped rod amphiphiles and studied the self-assembled structure and the character responded to the external environment, applying the transformation to the loading and releasing of hydrophobic and hydrophilic molecules.The examples of nanotube synthesis are too numerous to mention individually. Firstly, V-shaped aromatic aromatic amphiphiles(VM1) were synthesized through the synthesis of a series of specific structure intermediates(15 cases). The molecule was provided with p H response performance after we introduced methoxyl group. After investigating with ultraviolet-visible spectrophotometer, fluorophotometer, transmission electron microscopy, atomic force microscopy and circular dichroism, we found VM1 can self assemble into nano-tubular aggregates. When added acid, the construction of the tube changed, as well as th e chirality. Because of the formation of hydrogen bonds, the original close-packed arrays caused slipping, leading to the enlargement of the hexamer. According to the p H-responsive process, we succeeded in loading hydrophilic molecules(Doxorubicin) in aqueous solution and releasing hydrophilic molecules in acidic buffer.At the same time, the salt-responsive dumbbell-shaped aromatic amphiphiles(DM2) were synthesized through the synthesis of a series of specific structure intermediates(11 cases). By the means of ultraviolet-visible spectrophotometer, fluorophotometer, transmission electron microscopy, circular dichroism and dynamic light scattering, we found out that DM2 assembled into spheroidal aggregates with a certain number of hydrophobic gap in aqueous solution. When we added salt into the solution, ion concentration in the solution was enlarging. The effection between ion and hydrone altered the space distribution of the fle xible chain, leading to the translation from distorted molecular structure to planar construction. According to the salt-responsive process, we managed to load hydrophobic molecules(Nile red) in aqueous solution and release hydrophobic molecules in saline solution.