Fabrication And Application Research Of Microcapsules Of Phase Change Materials

Swainsonine can promote the proliferation of the bone marrow, bone marrow suppression can effectively deliver lethal radiation or high dose chemotherapy caused neutropenia and thrombocytopenia ensues, preliminary evidence swainsonine of human malignant tumors have a therapeutic effect. In the synthesis process swainsonine many chemists have applied the Olefin metathesis, double hydroxylation, acid reactions, Olefin metathesis catalyst used is generally expensive, and most synthetic route is relatively long, complicated operation. To overcome these shortcomings, we designed two lines relatively simplified synthetic scheme to build an indolizidine pyridine ring, thus achieving synthesis swainsonine, and with the reported build-indole-piperidine ring in the West is different, we West pyridine want to build this key intermediate in the unsaturated indole by reductive coupling of the molecule under the low-cost titanium intervention.This paper did some research related to the synthesis of swainsonine, we have the basis for a lot in the research literature on the design of two simple synthetic routes, restore critical reaction two synthetic routes are involved in low-valenttitanium coupling reaction. We were cyclohexanone protection akagane acid lactone and benzyl protected akagane acid lactone and dimethyl-4-amino butyric aldehyde, based on the synthesis of a series of bitter and during the reaction the compound related swainsonine respectively to do the research and intramolecular dimethoxy lactam carbonyl group conjugated, and an aldehyde carbonyl group of the lactam carbonyl molecules are coupled, Acetal disulfide and lactam carbonyl molecules Study on coupling. When exploring the reductive coupling dimethoxy lactam carbonyl group and the low-cost titanium involved, we tried a lot of different reaction conditions, were not our goal to give the unsaturated compound in the West pyridine indole, also has other related new compounds. When exploring the reductive coupling with the aldehyde carbonyl lactam carbonyl involved in low-valenttitanium, we found that Mg, TiCI4, THF reaction system is a new method for the synthesis of vicinal diol, Cp2TiCl2, Et3NHCl, TMSCI, Zn, Et3N, THF reaction system can be reduced to the hydroxy aldehyde carbonyl group. When exploring the reductive coupling disulfide lactam acetal and aldehyde carbonyl groups involved in low-valenttitanium, we found Cp2TiCl2, P (OEt) 3, Zn,4A molecular sieve reaction system can selectively restore acetal compounds to disulfide compounds thioethers, Reduction of disulfide acetal compounds into sulfide compounds similar thereto did not see the relevant reports. Optimal intermediates and related compounds without structure was identified by NMR or/and Ms.