Study On Preparation Technology Of Deoxyfuridine Nanoparticles

Nanoemulsion is a new type of drug carrier, it is by the oil phase, water phase, surfactant and surfactant components to help one to clarify the appearance of a transparent, isotropic, thermodynamics and kinetics of the system is very stable. As a model drug, we systematically study the preparation of doxiflurdine nanoemulsion.Selection of ethyl oleate as oil phase, soybean lecithin as surfactant, avantin to help to draw artificial three initiatives phase diagram.The size of nanoemulsion region-wide as an index to study the various components of the formation of the nanoemulsion impact; also investigated with the ratio of surfactant and aid-surfactant, as well as order and mixed-mode dispersion of the nanoemulsion formation, and ultimately determine optimal prescription and preparation process of the blank nanoemulsion and doxiflurdine nanoemulsion.Through staining method and conductance method,water-in-oil nanoemulsion was identified; nanoemulsion was the rules of the form of round or oval-shaped observed by transmission electron microscopy,with an average particle size of about 50nm, in line with the nanoemulsion size requirements;the entrapment efficiency of nanoemulsion was determinated by gel column chromatography,the method was simple, fast, accurate and the results of separating by sephadex column was stable, good reproducibility;we establish analysis methods of in vitro dissolution, and study doxiflurdine nanoemulsion process of in vitro release of the preliminary by dialysis bag diffusion method, the drug release curve was fit.