The Clinical Observation Of Hydroxyethyl Starch Extends Epidural Morphine For Postoperative Analgesic Efficacy

Objective: to observe analgesic efficacy of Hydroxyethyl starch with epidural morphinefor gynecological operation.Methods: Sixty patients (ASAI～II) at the age of25to66scheduled for gynecologicalsurgery were selected for the experiment. All patients were choosen from Yan’anUniversity Affiliated Hospital. The patients were randomly assigned into two groups, allreceived CSEA. The patients in group A (control group) received epidural morphine2mg (dilutes with0.75%levobupivacaine2ml and nature saline to10ml)， and those ingroup B (experimental group) received epidural morphine2mg (dilutes with0.75%levobupivacaine2ml and Hydroxyethyl Starch130/0.4to10ml) after surgery. Twogroups are disposable epidural administration, the epidural catheter was removed aftersurgery. All patients open peripheral vein and monitor signs of life routinely afterentering the operating theatre. The patients injected atropine0.5mg with intravenous30minutes before anesthesia, and midazolam0.05mg/kg, propofol3～5mg/kg·h10minutes before surgery, to make patients fully calm and go to sleep. After the surgery,the patients were sent into the postanesthesia care unit. Monitoring project:(1)Theduration of analgesia,(2)Side effects: such as headache, nausea, vomiting, itching, etc.(3)Pain score: VAS scoring was recorded at6,12,24,30,36,48,60,72h after operation. Results:1. There were no significant differences in age, height, weight, and ASA gradingamong two groups (P＞0.05).2. Experimental group was longer than the control group in postoperative analgesiatime, and there was significant difference (P＜0.05).3. There were significant differences in the incident of headache and nausea (P＜0.05) and no significant differences in the incident of vomiting and itching (P＞0.05).4. The VAS scores at24,30,36h after operation were lower in experimental groupthan in control group, and the differences were statistically significant (P＜0.05). Nosignificant differences were found in the VAS scores at6,12,48,72h in two groupsafter surgery (P＞0.05).Conclusion:1. Hydroxyethyl starch can prolong the time of epidural morphine analgesia afteroperation.2. Epidural hydroxyethyl starch can reduce the incidence of postoperative headacheand nausea.