The Study Of Anti-inflammatory Mechanism Of Polysaccharides For The Mycelium Of Hericium Caput-medusae

Polysaccharides have been used are the prevention and treatment of various diseases in thefield, e.g., infectious diseases, some cancers and a variety of immune related diseases. Researchindicates that the biological activity of polysaccharides with leukocytes, macrophages,combined with cell surface receptors, stimulating immune cells added value anddifferentiation. These activities regulating the natural immune response process and cellularimmunity, so the final play of the anti-tumor effect of sterilization.Human monocytic THP-1myeloma cell line the expression of Fc receptors may be phorbol12-myristate13-acetate (PMA) induced differentiation into macrophage like cells. After PMAtreatment, suspension culture cells become adherent cells, mitochondria, lysosomes increase inthe number of cytoplasmic nuclear ratio increases. Differentiation of the cell surface receptorafter differentiation of monocytes to macrophages is consistent. Moreover, it exhibits the latexparticles of superabsorbent, and the cell shape is also very similar to macrophages.Studies have shown that Ganoderma lucidum polysaccharides and GM-CSF/IL-4addedsimultaneously, can be induced monocytic THP-1cells into dendritic cells. Recent studies havefound, Ganoderma lucidum polysaccharides can induce cytokine secretion same cell lines andcell necrosis. Separated in Morchella mannan extract THP-1cells can increase the expression ofNF-κB.In this paper, through the establishment of monocyte-macrophage-like cell model of asmall thorn hedgehog fungus mycelium polysaccharide polysaccharide antitoxin effects analysis,the use of protein kinase inhibitors on NF-κB, protein kinase MAPK signaling pathway wereinhibition observed changes hedgehog spines fungal mycelium polysaccharide effects ofpolysaccharides. The results confirmed the hedgehog spines mycelium polysaccharide onTHP-1cell inflammation models have anti-inflammatory effects, for food and medicinal fungidevelop drugs and health products provides a theoretical basis to further enrich thepharmacological effects of fungal polysaccharides Research.