Nasal Rhabdomyosarcoma Four Cases And Literature Review

Object Through a retrospective study of nasal rhabdomyosarcoma cases,investigate its pathogenesis, clinical manifestations, treatment methods,in order to further improve the clinical understanding of the disease andtreatment.Materials and MethodsA retrospective analysis from2012to2014our department treated fourcases of nasal rhabdomyosarcoma patients with clinical and pathological data.ResultsAll cases have been confirmed by pathologic and immunohistochemical examination. Three of the patients≤21years old, are proptosis, blurredvision chief complaint admission.1case for elderly patients, the main with nasal congestion, exophthalmos with headache for the chief complaint to the hospital. Hospital physical examination: four cases wereseen in tumor and purulent nasal secretions white, all have differentdegrees of exophthalmos and double vision. All patients underwent nasal admission CT scan+MRI, blood count, biochemistry full examination.Two cases of patients were treated with endoscopic resection of tumor+radiotherapy+chemotherapy for a comprehensive approach. One caseof8-year-old children because of the large tumor volume, unresectable,taking pathology underwent radiotherapy and chemotherapy, died of complications after radiotherapy. Chemotherapy for1cases of elderly patients after operation, appear myelosuppression in chemotherapy, she did not received radiotherapy. Pathological type,3cases of embryonal rhabdomyosarcoma (2cases of young patients,1cases of elderly patients),1cases of alveolar rhabdomyosarcoma, Immunohistochemistry: For Ve mintin, Myolobin, Desmin, MyD01, Myogenin mark check, the positive rates were100%,75%,100%,75%and100%.. Minimum follow-up of more thanhalf a year, of which2patients with intracranial metastasis, died in1years, the remaining2cases still on treatment and follow-up, thesurvival condition.ConclusionsNasal rhabdomyosarcoma no characteristic clinical manifestations, rapid progression and poor prognosis, early diagnosis, comprehensive treatment can improve survival.