Association Between Lung Function And Metabolic Syndrome: An Analysis Of Cross Sectional Study Data From The Chinese Coastal Areas

Objective: The aim of this cross sectional study was to estimate the crude prevelanceof Metabolic Syndrome (MS) in the Chinese coastal areas, and to investigateAssociation between MS and Lung Function.Methods: The cross sectional study included2935local residents,aged30-75yearsfrom two counties in the Chinese coastal areas,who underwent questionnaireinvestigation,physical examination, laboratory examination and spirometric lungfunction test.According to the International Diabetes Federation (IDF)consensusworldwide definition of MS, all subjects were divided into two groups: MS andnon-MS. Single factor analysis including t-test, rank sum test and Chi-square testwere used to compare the differences in two groups,multiple linear regressionanalysis were used to assess the relation between lung function and MS adjusted forsex, age, height, weight, cigarette index and drinking history.Results: According to the IDF diagnostic standard, the crude prevelance of MS was18.9%, standardized rate was14.8%. Both the crude and standardized prevalence rateof MS were higher in females than in males(crude prevelance rate:23.2%/11.7%;standardization：17.8%/9.15%). FVC%Pred in MS group was lower than non-MSgroup in males, females,50-59years,60-69years and all subjects (t value：-2.03,P<0.05; t value：-4.257, P<0.001; t value：-2.912,P<0.05; t value：-3.746, P<0.001;t value：-5.423, P<0.001). In females and50-59years，FEV1/FVC in MS groupshowed lower than non-MS group (t value：-2.01,P <0.05; t value：2.263,P <0.05).In the relation between components of MS and lung function, with waistcircumference, systolic blood pressure, lnTG increased and HDL decreased,FVC%Pred declinced and tended to restrictive ventilation dysfunction. Model1was MS components respectively entered into multiple linear regression equation, model2was all the MS components entered into the equation.In model1, partial regressioncoefficient β and P values in linear regression equation of the above components(waist circumference, systolic blood pressure, lnTG and HDL) with FVC%Predwere(-0.127,<0.001),(-0.082,0.001),(-0.044,0.04),(0.042,0.049). In model2,lnTG and HDL had little impact on FVC%Pred, its corresponding β and P valueswere (-0.109,0.003),(-0.078,0.002),(-0.023,0.329),(0.035,0.115). In addition,with waist circumference and systolic blood pressure elevated, FEV1%Pred decreasedand tended to obstructive ventilation dysfunction, correspingding β and P value inmodel1were (-0.109,0.003) and (-0.065,0.009), in model2were(-0.096,0.009),(-0.06,0.017) respectively. Elevated FPG did not cause relatedventilatory function decline.Conclusions: Women carry more risks for MS than men.The MS group appears lowerlung function than non-MS group especially among females and the elderly.In thecomponents of MS, waist circumference and systolic blood pressure can make atendency of mixed ventilation dysfunction, indicating that abdominal obesity andhypertension are important predictors of lung function decline.