The Relationship Between Secretory Otitis Media And Gastroesophageal Reflux Disease And Its Clinical Significance

Objective Discussion secretory otitis media (SOM) and gastroesophageal refluxdisease (GERD) related factors, and to explore the clinical significance of both. Soas to provide new theoretical basis for clinical treatment for secretory otitis media.Methods Extraction of our hospital outpatient middle ear effusion in45cases ofpatients with SOM. During the same period in our hospital diagnosed22casesof otitis media patients as control. All cases were filled out the survey form indetail. After investigation, detection and clinical symptoms in the diagnosis ofGERD[1]. The pepsin in fluid using ELISA immunoassay were determined, and theirconcentrations were measured by enzyme labeled parallel correlation analysis. Alldata were analyzed by SPSS17.0.Results GERD was expressed in patients with SOM and simple otitismedia.45cases in group SOM with33cases of patients with GERD, the positiverate of GERD was73.3%;22cases of otitis media group with3cases of GERDpatients, the positive rate of GERD was13.6%. Using ELISA and P/N method,33cases of GERD were detected in13cases of middle ear effusion of pepsin, thepositive rate was39.3%. The pepsin dilution was0.1μg/ml～10μ g/ml, madeaccording to the standard curve of absorbance and concentration relationship at450nm. According to equation can be measured pepsin content in middle eareffusion was (0.66±0.46μ g/ml).Conclusion SOM may be associated with GERD. Middle ear Pepsin exists asa manifestation of GERD esophagus, may in the future through the treatmentof GERD with acid reflux induced SOM. Through the inhibition of gastricacid reflux, control pepsin retrograde moves into the middle ear nasal pharynx andeustachian tube, which can avoid the patients undergoing tympanostomy andother invasive treatment, in order to provide new theoretical basis for the clinicaltreatment of SOM.