Risk Factors For Motor Complications In Parkinson’s Disease: A Retrospective Study

Objective: To study the relevant risk factors by assessing the PD patients withmotion complications after long-term use of levodopa.Methods: We collected the information of94cases of clinic diagnosis of primary PDpatients, including age, sex, age of onset, course of diseases, levodopa usage, mergeagainst Parkinson’s drug use situation, smoking, drinking, drinking tea, exposure totoxic substances. We used t test, the Mann-Whitney U nonparametric test,chi-squaretest and Fisher’s exact probability method to compare differences between groups.Wealso used Logistic regression to analysis the above factors in order to look for the riskfactors associated with motor complications of parkinson’s disease. We alse picturedK-M survival curves to describe l-dopa treatment and movement trend of motorcomplications.Results: We found that age of onset, course of disease, course of treatment, dailydose of LD,average daily dose of LD and smoking were related to dyskinesia (P <0.05); Course, daily dose of LD, average daily dose of LD were associated withmotor fluctuation (P <0.05). The age of onset was the risk factor of dyskinesia.Course of the disease and average daily dose of LD were risk factors of motorfluctuation.Conclusion: Age of Onset was the risk factor of dyskinesia, duration and averagedaily dose of LD were risk factors of motor fluctuation. Survival curves indicated thelong-term use of levodopa could increase the incidence of complications.