| Objective: In order to explore underlying mechanisms of the difference in mortalityof gastric cancer between Nanjing County and Minqing County which are located inmountainous areas of Fujian Province and to study the infection rates of helicobacterpylori (H. pylori) and serum pepsinogenⅠ,Ⅱ(PGⅠ,Ⅱ), PGⅠ/Ⅱ ratio (PGR) andgastrin-17(G-17) in the residents from the two counties, and to further analyze thepossible influence factors of these serological parameters, our group has carried outthis study.Methods: In this study, we used the multi-stage random sampling method to recruitqualified subjects and used questionnaires to investigate the family history and thediet habits of the subjects in Nanjing County and Minqing County. Fasting bloodsamples were taken and the levels of serum PGⅠ, PGⅡ, G-17and H.pylori antibodywere measured. The differences of family history, diet habits, the infection rates ofH.pylori and the levels of PGⅠ, PGⅡ, PGR and G-17between two counties, and thepossible influence factors of serological parameters as well were analyzed.Results: Totally231subjects were recruited in Nanjing including136males (58.9%)and95females (41.1%). The average ages were49.5±9.9years old. In Minqing224subjects were recruited including117males (52.2%) and107females (47.8%). Theaverage ages were50.2±10.0years old. The analysis of family history indicated thatthe percentages of the subjects with the first-degree relatives (parents, grandparents,brothers and sisters) suffering from upper gastrointestinal cancer in Minqing weresignificantly higher than those in Nanjing (P=0.005). As compared to the subjects inMinqing, the subjects in Nanjing paid more attention to nutritional balance.Consumption of fruits, kelp, tea, dried sweet potatoes, ginger, lean meat and lardo were significantly more frequent in Nanjing than in Minqing (P＜0.05). However,consumption of pickle, processed meat, processed fish and fish sauce weresignificantly more frequent in Minqing than in Nanjing (P＜0.05). On the other hand,the percentages of the subjects with smoking habit were higher in Nanjing than inMinqing (P＜0.05). The infection rates of H.pylori and the proportions of abnormalserum G-17were significantly higher in Minqing than in Nanjing (P＜0.05).Univariate analysis showed that the factors such as male, getting older, less intake ofvegetables, smoking and H.pylori infection might result in significantly higher levelof PGⅠ(P＜0.05); getting older, less intake of tea and H.pylori infection might resultin significantly higher level of PGⅡ(P＜0.05); getting older, less intake of tea andH.pylori infection might result in significantly lower level of PGR (P＜0.05);smoking and H.pylori infection might result in significantly higher level of G-17(P＜0.05); besides, getting older, less intake of tea might influence the infection rate ofH.pylori. Multiple linear regression analysis showed that the level of PGⅠwaspositively correlated to the age, smoking and the level of H.pylori antibody, whilereversely correlated to the intake of green vegetables; the level of PGⅡwas positivelycorrelated to the level of H.pylori antibody and the age, while reversely correlated tothe intake of tea; the level of PGR was reversely correlated to the level of H.pyloriantibody and the age; in addition, no factors which might influence the level of G-17were observed. Moreover, unconditioned binary logistic regression analysis showedthat smoking and the intake of pickles might increase the risk of abnormal level of PGⅠ,with the odds ratio (OR) of2.193,1.937, respectively. The intake of pickles mightincrease the risk of abnormal level of PGR, with OR of1.851. Furthermore, the riskof abnormal level of G-17might be increased by H.pylori infection, with OR of1.577.Finally, the intake of tea might decrease the risk of H.pylori infection, with OR of0.737.Conclusions: As compared to the residents in Nanjing, the residents in Minqing had ahigher incidence of upper gastrointestinal cancer in their first-degree relatives, lesshealthy diet habits, higher levels of H.pylori infection rates and higher proportions ofabnormal serum G-17. These results might suggest that the residents in Minqing have a higher risk to develop gastric cancer as compared to those in Nanjing, which mightexplain the reasons why the mortality rate of gastric cancer in Minqing was higherthan that in Nanjing.The factors such as age, the intake of tea and green vegetables, smoking andH.pylori infection might influence the levels of PGⅠ, PGⅡ, PGR and G-17; thefactor such as age and the intake of tea might influence H.pylori infection. the factorssuch as smoking, intake of pickles, H.pylori positive might increase the risk ofabnormal levels of PGⅠ, PGⅡand G-17, respectively; while intake of tea mightdecrease the risk of H.pylori infection. |
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