Correlation Between Transient Elastography (Fibrotouch) Measurement And The Cliilical Diagnosis In Chronic Hepatitis B

ObjectiveTo explore the Transient Elastography（Fibrotouch） application value in chronicHBV infection.MethodsFibrotouch tests from our hospital250cases of healthy control group, chronichepatitis B, liver cirrhosis after hepatitis B, liver stiffness values (LSM), analysis ofliver hardness value of the difference between three groups; The analysis of the effectof age and gender for detecting Fibrotouch LSM value；Chronic HBV infection LSMvalue analysis and biochemistry index, imaging diagnostic level of difference andcorrelation.Results①. The health control group of100cases of chronic hepatitis B group of102cases,hepatitis B cirrhosis group30cases. Chronic hepatitis B cirrhosis group had asignificantly higher values of LSM group and healthy group (P <0.05), chronichepatitis B group was significantly higher than that of control group (P <0.05).②The LSM values to compare differences between age groups have statisticalsignificance (P=0.031). Youth LSM value is lower than the elderly group (P=0.001), middle age group of LSM value is lower than the elderly group (P=0.004),but the young and middle-aged group LSM value comparison difference has nostatistical significance (P=0.727). The LSM in men is more than women.③The LSM value and clinical examination indexes nonparametric Spearmancorrelation analysis, the results suggest the LSM value with TBIL, ALT, AST, GGTwere positively correlated, r were0.421,0.347,0.376,0.392, and a negativecorrelation between propagated, r=0.371.④Different imaging diagnostic level grouping of LSM value difference wasstatistically significant (P <0.05), the correlation between LSM value and imagingdiagnosis level grouping is good (r=0.661). Conclusion(1) Fibrotouch is a quantitative test method for hepatic fibrosis, is simple, rapid,noninvasive, safe and repeatable, more accurate assessment or dynamic reviewfibrosis degree.(2) Gender, age, may have an effect on LSM Fibrotouch detection value, and ahardness value of men than women, youth LSM value is lower than the elderly group,middle-aged group of LSM value is lower than the elderly group, but the young andmiddle-aged group there was no statistically significant difference value of LSM.(3) LSM values were significantly higher in patients with cirrhosis patients withchronic hepatitis b, healthy group, patients with chronic hepatitis b LSM value wassignificantly higher than that of healthy people, tip the LSM value associated with theseverity of disease, severity in the diagnosis of chronic HBV infection fibrosis hasgood application value.(4) Chronic HBV infection in LSM value was positively correlated with TBIL, ALT,AST, GGT, correlation coefficient,and a negative correlation between propagated.LSM Fibrotouch detection value may be affected by patients biochemical factors.(5) Fibrotouch measurements and imaging diagnosis level exist linear correlation, andhas a good correlation.(6) Fibrotouch detection LSM value in the diagnosis of patients with liver fibrosisdegree should be comprehensive etiology, laboratory examination and imagingexamination, etc., in order to improve the accuracy of detection.