Analysis Of Risk Factors For Pulmonary Bacterial Infection After Orthotopic Liver Transplantation

Objective: To analyze the incidence of pulmonary bacterial infection after orthotopicliver transplantation and its risk factors.Method: ninety-six patients with end-stage liver disease underwent livertransplantation from January2010to june2012were retrospectively analyzed in ourhospital. They are divided into lung infection group (29cases) and non infectiongroup (67cases).The12independent variables of preoperative, intraoperative andpostoperative, by univariate analysis and multivariate non-conditional logisticregression analysis, to determine the risk factors associated with early postoperativepulmonary bacterial infection.Results：1.29cases of96cases after liver transplantation occurred early pulmonary bacterialinfection, infection rate was30.20%(29╱96), G_aerobic bacteria infectionaccounted for65.52%(19╱29)，G+aerobic bacteria accounted for34.48%(10╱29).The klebsiella pneumoniae and e. coli are the most common among them.2. Univariate statistical analysis for early postoperative pulmonary bacterial infectionfound:statistically significant indicators (P <0.05) are: Patients with smoking≥20╱day, Preoperative Meld score, ascites, intraoperative blood transfusion,postoperative3day average creatinine, postoperative hospitalization days and threedays after liquid negative balance time. These factors are analysised by unconditionedlogistic binary regression analysis, statistically significant factors (P <0.05) are:Preoperative Meld score, intraoperative blood transfusion, postoperative3dayaverage creatinine, postoperative hospitalization days and three days after liquidnegative balance time.Conclusion： Retrograde reperfusion in orthotropic liver transplantation patients aresusceptible to bacterial pulmonary infections, espesially,gram-negative bacteria.Preoperative Meld score, intraoperative blood transfusion, postoperative3dayaverage creatinine, postoperative hospitalization days, three days after liquid negativebalance time is associated with early postoperative pulmonary bacterial infections.thus, controlling intraoperative blood transfusion volume, the volume of transfusionand postoperative hospitalization time, improving renal function can reduce earlypostoperative pulmonary bacterial infection.