Association Between The Heart-type Fatty Acid Bindmg Protein And Cardiac Function In Patients With Chronic Heart Failure

Objective To estimate the clinical significance and relativity of heart-type fatty acid binding protein brain natriuretic peptide and cardiac tropohin I in patients with chronic heart failure.Methods The chronic heart failure patients were divided into three groups according to the New York Heart Association classification scheme, of which12cases with heart function II,15cases with heart function Ⅲ,25cases with heart function IV, and20cases without chronic heart failure as the control subjects. Serum concentrations of heart-type fatty acid binding protein、brain natriuretic peptide and cardiac troponin I were measured in all the seleceted subjects. Then analyzing their association with the heart function.Results (1) The levels of H-FABP in patients with heart function Ⅱ、Ⅲ、Ⅳ were higher than the control group. There was significant statistically differences among the four groups (P<0.001). Correlation test-showed that level of H-FABP was directly correlative with heart function (r=0.961, P<0.001).(2) The levels of NT-proBNP in patients with heart function Ⅲ、Ⅳ were higher than the control group. There was significant statistically differences among the three groups (P<0.001). There was no significant statistically differences between the heart function Ⅱ and control group (P>0.05). Correlation test showed that level of NT-proBNP was directly correlative with heart function (r=0.872, P<0.001)(3) The levels of cTnl in patients with heart function Ⅱ、Ⅲ、Ⅳ、were higher than the control group. There was significant statistically differences among the four groups (P<0.001). Correlation test showed that level of cTnI was directly correlative with heart function (r=0.954, P<0.001).(4) Spearman correlation test showed that level of H-FABP was directly correlative with the level of NT-proBNP (r=0.635, P<0.001) and so was cTnI (r=0.946, P<0.001)Conclusions The plasma concentration of H-FABP has obvious correlations with the severity of heart failure. The level of serum H-FABP had a significant positive correlation with NT-proBNP and cTnI.The combined application of the three above is valuable for risk stratification in patients with chronic heart failure.