Influence Of Intracoronary Administration Of Tirofiban Bolus In Patients Undergoing Primary Percutaneous Coronary Intervention On A-granule Membrane Protein140and Myocardial Perfusion

Objective:To investigate the influence of intracoronary administration of tirofiban bolus in patients with acute ST segment elevation myocardial infarction (STEMI) undergoing emergency percutaneous coronary intervention(PCI) on platelet activation, myocardial perfusion and heart function.Methods:Seventy patients with acute myocardial infarction who underwent emergency PCI within12hours were randomly divided into2groups due to the random number table method:tirofiban group(35patients)and control group(35patients);male(49) and female(21). The tirofiban group additionally received intracoronary tirofiban hydrochloride injection of10μg/kg before bracket implantation during PCI. The control group received bracket implantation directly. To observe the changes of platelet activation (platelet a grains membrane protein) during PCI, advance level of troponin I12h after PCI and difference of NT-proBNP between1day and7days after PCI of the2groups.Results:The GMP140concentrations of tirofiban group(17.99±1.01)μg/L were lower than control group(24.56±1.96)μg/L; there was statistics difference between the2groups (P (0.01). The advance level of troponin I12h after PCI of tirofiban group(50.96±2.20)ng/ml was lower than control group(58.69±2.34)ng/ml; there was statistics difference between the2groups (P (0.01). The difference of NT-proBNP between1day and7days after PCI of tirofiban group(894.19±90.91) was higher than control group(829.50±84.18); there was statistics difference between the2groups (P (0.05) Conclusion:Intracoronary administration of tirofiban bolus in patients with STEMI undergoing acute PCI can inhibit platelet activation, improve myocardial perfusion and benefit to the recover of heart function.