Effect Of High Frequency Oscillatory Ventilation On Oxygenation During One-lung Ventilation

Objective: To compare the effect of high-frequency oscillatory ventilation (HFOV)and conventional mechanical ventilation (CMV) on oxygenation during one-lungventilation(OLV), discussing the application of HFOV in OLV, and wether HFOV have itsadvantage over CMV.Method:10patients scheduled for thoracic surgery,including9males and1femaleshad been received OLV after induction of anesthesia(right lateral decubitus,ventilate theright lung),after20min of CMV,the patients were first ventilated with HFOV for20min,then switched to CMV for20min. During each mode of ventilation,at the ventilation timeof5min（T1）,10min(T2),15min(T3), and20min(T4),blood pressure, heart rate and pulseoxygen were recorded and at the end of each ventilation, radial artery blood was collectedfor gas analysis, recording PaO2, PaCO2, pH and SaO2.Results: When switched from HFOV to CMV, arterial partial pressure of oxygen(PaO2) decreased from (210.90±124.19) mmHg to (162.80±102.83) mmHg, P=0.023<0.05; at the same time, arterial partial pressure of carbon dioxide (PaCO2) decreased from(60.00±9.04)mmHg to (52.60±12.30) mmHg, P=0.045<0.05; both PaO2/FiO2(P=0.241),pH (P=0.286) and SaO2(P=0.173) analysis had no significant difference. the MAP,andheart rate of the to kinds of ventilation had no significant difference (P>0.05).Conclusion: During OLV, HFOV had better oxygenation than conventional volumemechanical ventilation;at the same time, HFOV had no significant effect on HR and ARTcompared with CMV.