A Relative Research Between Serum ECP, IgE, Peripheral Blood Eosinophils And Bronchial Asthma In Children

Objective To investigate the relationship between serum ECP, Total IgE, eosinophils counts and severity of bronchial asthma in children; To understand the categories of allergens in children with bronchial asthma and provide scientific basis for its prevention, condition judgment and therapy.Methods According to the classification standards of children with asthma severity,95cases of asthma were divided into intermittent episodes of group (n=23), mild group (n=29), moderate group (n=23), severe group (n=20).20cases of healthy children were selected as a control group. The serum levels of ECP, TIgE and SIgE were quantitatively measured by ImmunoCAP100E automated system. Eosinophil counts were detected by Sysmex XT-2000i Hematology Analyzer.Results In95cases of children with asthma, the positive rate of inhalant allergens sIgE was71.58%which house dust mites, dust mites and house dust mainly accounted for69.47%,68.42%and32.63%, respectively. The positive rate of ingested allergens sIgE was22.11%which shrimp and crab mainly accounted for21.05%and18.95%, respectively. The serum levels of ECP between each asthma group and the control group, among the mild, moderate and severe groups were significantly different, P<0.05,the highest value appeared in the severe group. The serum levels of TIgE among the mild group, intermittent episodes and control group showed no significant differences, P>0.05.Peripheral blood eosinophils between each asthma group and the control group were statistically significant differences, P<0.05,but between severe and moderate, moderate and mild, mild and intermittent group were not statistically significantly different, P>0.05.The serum level of ECP was positive correlation with TIgE and eosinophil counts (r=0.615,P<0.01;r=0.533,P<0.01).The serum level of TIgE was positive correlation with eosinophil counts (r=0.239,P<0.05).Conclusions The serum levels of ECP reflect the degree of airway inflammation more accurate and sensitive than TIgE and eosinophil counts. ECP can be detected as a clinical objective indicator of airway inflammation. House dust mites, dust mites and house dust were major allergens causing asthmatic attack in children over3years.