Analysis Of LGT Different Expression And Long-term Survival Using FOLFOX Chemotherapy After Colorectal Cancer Surgery

[abstract] objective:to study the different expression of LGT and Long-term survival of FOLFOX chemotherapy after colorectal cancer surgery.Methods:choose55patients use surgical treatment of parallel colorectal,between January2006to January2009.All the patient detect SELDI to get the map of fingerprint,use four to six cycles of FOLFOX chemotherapy,follow-up to August2011. Adifferent age, gender, LGT express or not, under the conditions of disease progression of survival and without a median of two groups of the differences. Results:In the absence of survival and disease progression median survival were no significant difference (7.85,6.50, P=0.770;15.75value:13.00, P value=0.517)between≥65years old group and<65years old group;There is no significant difference among the men and women group (8.50,4.95, P=2.057;17.00value:10.00, P value=1.622). No disease progress for a median is2.8months in LGT positive patient,10months in LGT negative patient(P value=0.000).Progress for a median is5.85months in LGT positive patient,18.5months in LGT negative patient(P value=0.000). Conclusion:Both the no disease progress for a median and progress for a median in LGT positive group is far lower than the LGT negative group.Suggestion:before the operation such as LGT positive for express, first control LGT, LGT expression to normal after poste operation, to ensure that the treatment effect.