Clinical Significance Of Determination Of Serum Procalcitonin In Patients With Severe Infection

Bacground:Severe infection is induced by septic shock and multiple organ failure syndrome(multiple organ dysfunction syndrome.MODS). Looking for a new reaction with high specificity and sensitivity of the index, it is necessary to.The World Health Organization in recent years of procalcitonin research and more and more attention, Many of these studies in patients with bacterial infection,For the dynamic observation of viral infection and severe bacterial infections in the study of calcitonin levels not much.Especially in the respiratory intensive care unit patients has not been reported in research.This research through to the infection in patients with serum calcitonin level of dynamic test, for clinical identification of infection type and effect evaluation provide a scientific basis.Objective:To detect patients with severe infection in serum calcitonin original (procalcitonin, PCT) determination of clinical significance.Methods:The detection of serum PCT and its dynamic changes of76patients in RICU departments were analyzed. The patients were divided into normal infection group (group A), serious infection group (group B), virus infection group (group C), and in the2th day,3th day,5lh day,7lh day,9th day, The electrochemical luminescence method is adoptedthe to detect different expression of PCT evaluation. Each group on the same day and time detects peripheral C-reaction protein (C-reaction protein, CRP), hemameba (hemameba, WBC) levels as a reference.Results:The diction results of in patients of hospital the second day of three groups: serious infection group PCT, CRP, WBC respectively was (18.9±5.0) ug/L、(58.8±19.2) g/L、(15.8±9.2)×109/L, higher than patients with group PCT、CRP、WBC respectively was (2.7±0.8) ug/L、(37.3±12.4) g/L、(11.4±3.5)×109/L; The diction results of normal infection group patients was higher the virus infection group with PCT、CRP、WBC respectively was (0.6±0.2) ug/L、(15.2±8.4) g/L、(8.7±1.2)×109/L, and the difference was statically significant (P<0.05); serious infection in patients with serum concentration of procalcitonin expression for (18.9±5.0) ug/L, significantly higher than patients with normal infection (2.7±0.8) ug/L, P=0.000; normal infection in patients with serum concentration of procalcitonin expression for (2.7±0.8) ug/L, significantly higher than patients with virus infection (0.6±0.2) ug/L, P=0.000. After3days receiving effective antibiotic therapies, procalcitonin levels in both of bacterial infection group compared with before treatment were significantly decreased (P=0.000); The overall comparison between the dreiergruppe patients(variance of single factor analysis):the difference was statically significant (P<0.05);Pairwise comparison (LST test):normal infection group and serious infection group, virus infection group and serious infection group, the difference was statically significant (P<0.05); The change of concentration of procalcitonin expression showed a trend of tie decay; With the extension of observation time,patients with serum procalcitonin concentrations gradually reduced.Conclusion:1. The detection of serum procalcitonin has a certain value for the diagnosis of clinical bacterial infection and evaluation of infection degree;2.Continuous detection of PCT in patients with bacterial infections expression concentration showed a trend of time decay;3.Serum PCT can help clinicians preliminary reasonable use of antibiotics.