| Background and ObjectivePrehypertension is the transitional phase between normal blood pressure and hypertension, easily progressing to hypertension. Prehypertension is the result of combined effects of multiple cardiovascular risk factors. Recent studies have found that insulin-like growth factor1(IGF-1) was involved in the pathogenesis of hypertension, hypertensive target organ damage, and vascular remodeling. The purpose of this study is to explore the constitute of risk factors associated with prehypertension, and the relationship between serum IGF-1and prehypertension.MethodFrom May2011to May2012, it was using sampling method to select40to70-year-old non-hypertension residents who was living in six districts in Tianjin for the study. The subjects were divided into the prehypertension group and the normal blood pressure group based on the standard of "Hypertension Prevention Guideline of China (Revised2010)". The age, gender, smoking and alcohol consumption, family history of hypertension, history of diabetes and hyperlipidemia disease, height, weight, waist, hips, and other general information were collected. Blood samples and morning urine were taken to detecte biochemical parameters. SPSS17.0software was used for statistical analysis. Normally distributed measurement data were expressed as mean±standard deviation (x±s). Independent sample t-test was used between the two groups with, and One-Way ANOVA analysis of variance was used. Categorical variables were expressed as composition ratio and comparing among groups used chi-square test. Logistic regression analysis model wsa used to analyze the risk factors. P<0.05was considered statistically significant.Result1, Incidence of prehypertension increased gradually with age. Prehypertension group is higher than normal blood pressure group in the incidence rate of smoking, alcohol consumption, overweight and obesity, central obesity, high TC, high TG and low HDL-c, diabetes, IGT, high uric acid, and the proportion of women is lower, the difference was statistically significant (P<0.05); the proportion of family history of high blood pressure and high LDL-C, IFG incidence tended to increase in prehypertension group than in the normal blood pressure group, but the difference was not statistically significant (P>0.05). Risk factors Logistic regression analysis showed:male gender, smoking, drinking, high BMI, high TC, high TG, high blood sugar, high uric acid are related risk factors for prehypertension (P<0.05). The proportion of prehypertension combination of one or more risk factors is97.55%. The proportion of prehypertension group is higher than normal blood pressure group (97.55%vs79.83%, P<0.05).2, Serum uric acid levels of prehypertension group is higher than normal blood pressure group (303.81±74.63vs273.33±68.79, P<0.05). Blood pressure, BMI, TG, Scr and eGFR gradually increased with serum uric acid levels, and HDL-c gradually decreased (P<0.05). Serum uric acid levels is a linear relationship with prehypertension risk between200to420μmol/L.3, Serum IGF-1levels in prehypertension patients is higher than normal blood pressure group (114.81±62.62vs99.48±52.08μg/L, P<0.05); the ORs for prehypertension of the second, third, and fourth IGF-1quartiles were1.32(95%CI:0.62-2.63),1.93(95%CI:1.06-2.94), and2.28(95%CI:1.41-3.73, P<0.05), compared with the first group as a reference, and the frequency of prehypertension was significantly higher in the high IGF-1group. With the increase in blood pressure, serum IGF-1levels increased (82.73±54.05vs93.85±57.64vs122.69±56.41;99.69±56.62vs103.56±54.69vs118.47±59.54μg/L, P<0.05).Conclusion1, Middle-aged and aged prehypertension crowd of Tianjin has gathered a number of cardiovascular risk factors.2, Serum uric acid level can be independently increased the risk of prehypertension.3, The level of serum IGF-1was an independent risk factor of hypertension. |
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