Clinical Study Report On Postoperative Analgesic Effect And Hemostasis Effects Of Using PMMA To Reconstruct Iliac Bone Defect After Iliac Bone Harvesting

Research background and Objective：Autogenous bone graft is still the gold standard to fill the bone defect for bone union,osteomyelitis, bone tumor and so on. Iliac bone is the most commonly site to harvest. Thereare lots of factors to have to concern the location of bone harvesting, including the volumeof quantity demanded, the risk of potential complication, age, sex, BMI, bone mineraldensity. Because the bone volume which could be afforded more than20-30ml is strong, theposterior iliac crest is always being the first considerable location to be harvested for fillingthe large bone defect. But there are several complications for iliac crest harvesting havebeing described, including chronic pain, infection, hematoma, nerve injury, artery injury,bone fracture, hernia, joint injury. The chornic pain is the most reported complication. Itsrate is ranging from15.2%to49.3%. Especially for posterior iliac crest, the rate of chronicpain is ranging from5.1%to14.3%. Furthermore, the rates of infection, haematoma,fracture, and hypertrophic scar were significantly higher than the anterior iliac crest.How we could reduce the rate of complications has been focused on. Several reportshave put forward their own views, including minimally invasive therapy, tampinghemostasis material, placed drainage tube after surgery. But the result is not verysatisfactory. The purpose of our study was to try to use a new technique by PMMA fillingup the defect for reducing the rate of complications.Methods：78patients were divided into two groups.14patients were accepted by using PMMAto fill the bone defect.64patients were accepted bone wax. The doctor was required torecord pain degree and the drainage volume during postoperative1day,2day,3day,5day, 7day, respectively and the drainage tube removal time.Results：Statistics show that the first day after surgery, the pain scale was no significantdifference between two groups (P=0.140). On the second, third, fifth, seventh day,respectively, the PMMA group was significantly lower than the control group. The P valuewas0.002,0.002,0.016,0.018, respectively. The drainage of PMMA group weresignificantly lesser than the control group.(P=0.023,0.021,0.023,0.025,0.011,respectively.) The removal time of the PMMA group was also shorter than the controlgroup.Conclusion: To reconstruct the bone defect of donor sites using PMMA could beconcerned a new method.