Clinical Studies Xijiaodihuang Decoction Chronic Immune Thrombocytopenia

Objective：Through observation Xijiaodihuang decoction decoction for treatingchronic immune thrombocytopenia (Chronic Immune Thrombocytopenia， CITP)clinical signs and symptoms，TCM symptoms，peripheral blood platelet count (plateletcount， Plt)， platelet-associated immunoglobulin efficacy (platelet associatedimmunoglobulin，PAIg) and reticulated platelets (reticulated platelets，RP) changes incircumstances， determine Xijiaodihuang decoction decoction for treating chronicimmune thrombocytopenia and to explore the possible chronic autoimmunethrombocytopenia disease mechanisms．Method：1．42patients with chronic immune thrombocytopenia patients from February2012to February2013at the Hospital of Henan Province， consistent with thediagnosis，according to the random assignment cards divided into treatment group andcontrol group，two groups each accounted for21cases．The treatment group receivedXijiaodihuang decoction decoction combined with prednisone therapy，the controlgroup was given prednisone therapy alone to28days for a course of three treatmentswas observed．2．Patients in both groups before treatment，after treatment，treatment for3-5daysby the automated analyzer to check the number of platelets in blood analysis；beforetreatment, after treatment by Kang Sheng Group Global Medical Special Inspectionconventional detection method using flow cytometry line detection ofplatelet-associated immunoglobulin (Indicators based in PAIgG) and reticulatedplatelets levels；before and after treatment, respectively，electrocardiogram，bloodclotting function and safety indicators，such as liver and kidney function checked．3．Changes were compared before and after treatment of symptoms and signs，TCM symptoms，peripheral blood platelet count， platelet-associated immunoglobulinand reticulated platelets and give statistical analysis concluded． Results:1．Clinical efficacy：efficacy of the number of cases in the treatment group asfollows：markedly good effect，progress，invalid respectively14，4，2，1；effect ofthe number of cases in the control group were：markedly good effect，progress，namely7，5invalid，4，5；groups of the total efficiency of95.24%，76.19%respectively；always a statistical analysis of the efficiency of the treatment group was higher thanthe total efficiency，there is a total difference between the two groups after treatmentwas significant compared to the efficiency；2．The number of platelets：the treatment group and the control group aftertreatment was significantly higher than the number of platelets before treatment， thetreatment group compared between the two groups than in the control group increasedsignificantly；3．Platelet-associated immunoglobulin：the treatment group and the control groupafter treatment than before treatment significantly decreased platelet-associatedimmunoglobulin treatment group compared between the two groups was significantlydecreased compared with the control group；4．Reticulated platelet levels：the treatment group and the control group aftertreatment reticulated platelets decreased significantly compared with before treatment，the treatment group compared between the two groups was significantly decreasedcompared with the control group；5．TCM symptoms terms of efficacy：efficacy of the number of cases in thetreatment group as follows：clinical cure，effective，effective，ineffective were3，12，4，2；effect of the number of cases in the control group were：clinical cure，effective， effective，ineffective， respectively1，7，7，6；groups were total efficiencyof90.48%，71.43%； statistical analysis of the treatment group syndromes totalefficiency higher total efficiency，the two groups after treatment syndromes total therewere significant differences in the efficiency of the treatment group than the controlgroup．Conclusion:1． Xijiaodihuang decoction decoction can significantly improve the clinicalsymptoms of chronic immune thrombocytopenia， and significantly improve theperipheral blood platelet count，indicating that the therapeutic effect of this approach iscertainly；and treatment side effects and adverse reactions were significantly notappear． 2． Xijiaodihuang CITP decoction decoction of TCM symptoms improvesignificantly better than prednisone．3．Xijiaodihuang decoction decoction treatment CITP Probable Mechanism：Through this research found that this decoction can reduce the level of peripheralblood platelet-associated immunoglobulin and reticulated platelets，thereby inhibitingthe generation of anti-platelet antibodies，thrombocytopenia damage and the generationand release of platelet increase，reaching elevated platelet counts purposes；You canalso generate direct knowledge of the situation of platelets in the bone marrow，todetermine the efficacy of some degree of significance CITP．...