Clinical Study On The Curative Effect Of The Method Of Strengthen The Spleen And Clear The Liver In Treatment With Depression Or Dys-thymia Insomnia

Objective: Discussed the effect of stagnant earth and depression of the livercaused by dysfunction of the spleen and stomach in the TCM etiopathogenisis andpathogenesis of depression or dys-thymia insomnia. Observed the curative effect ofthe method of strengthen the spleen and clear the liver in treatment with the mild tomoderate level of depression or dys-thymia insomnia compared with antidepressant.Provided theory and data support for treating this disease by regulating spleen andstomach. Provided a new method for Chinese medicine treatment of depression ordys-thymia insomnia.Method: Using clinical research guiding principles for clinical study of newChinese medicine treating insomnia published by Ministry of health in1993anddiagnostic criteria of psycholepsy in the Chinese Classification and Diagnosis ofMental Diseases-3rd edition (CCMD-3) selected cases of depression or dys-thymiainsomnia, and general evaluated these patients using the diagnostic criteria ofstagnation of liver-QI with deficiency of the spleen in clinical research guidingprinciples for clinical study of new Chinese medicine treating syndrome of stagnationof liver-qi and spleen deficiency.60cases were included in the study after agreementof themselves, and divided into two groups,30cases in treatment group and30casesin control group. Patients of treatment group were given traditional Chinese medicine(codonopsis20grams, poria cocos30grams, atractylodes10g grams, pinellia12grams, radix bupleuri10grams, raw dragon’s bone20grams, raw oyster shell20grams, white peony root20grams, Fried jujube kernel15grams, coix seed30grams,arisaema with bile10grams, bamboo shavings15grams, curcuma root15grams,liquorice6grams), decoction, one dose a day, morning and evening hours service.Patients of control group were given Paroxetine Hydrochloride Tablets, once a day,20mg, take orally. The two groups received different treatment for six weeks. UseHamilton’s depression scale (HAMD) and Pittsburgh Sleep Quality Index scale (PSQI) to evaluate these patients of the two groups, before and two weeks, four weeks,and six weeks after the treatment. Compared the difference between the treatmentgroup and the control group before and after the treatment. Used Asberg scale toevaluate the two groups and compared the side-effects of the two treatment method ofdepression or dys-thymia insomnia.Results: all of the60patients completed the clinical trial according to the plan,non-shedding and exclusion cases. The total effective rate of the treatment group is93.3%, and90.0%of control group. there was no significant difference between thetwo groups（P>0.05）. However the efficiency rate of treatment group (73.3%) wassignificantly higher than that of control group(46.7%)（P<0.05）. The PSQI of the twogroups were both dropped obviously after the treatment, there were significantdifferences within both the two groups（P<0.05）,while there was no significantdifference between the two groups（P>0.05）. But sleep efficiency score and thedaytime function score were significantly lower those of control group after thetreatment（P<0.05）. After the treatment the total HAMD scores were both reducedcompared with that before the treatment. There were significant differences withineach group（P<0.05）, and there wasn’t between the two groups（P>0.05）. Theeffective rate based on the TCM syndromes of the treatment group is73.3%, and thatof the control group is46.7%. The curative effect of treatment was better than that ofthe control group, and there was significant difference（P<0.05）. The Asberg score ofthe two groups was no significant difference between the two groups before thetreatment, But the score of the treatment group was significantly lower than that of thecontrol group after the treatment（P<0.05）.Conclusion: Both strengthen the spleen and clear the liver treatment oftraditional Chinese medicine and paroxetine are effective on depression or dys-thymiainsomnia. Both of them can improve the sleeping situation, lighten the depression, andreduce the severe of Chinese medicinal syndrome of depression or dys-thymiainsomnia patients. There is no significant difference between the two methods onimproving the sleeping situation, lightening the depression. Strengthen the spleen andclear the liver treatment is superior to paroxetine in reducing the severe of Chinesemedicinal syndrome and improving the sleep efficiency and the daytime function ofthe dys-thymia insomnia patients. And it has fewer side effects than paroxetine.