| ObjectiveTo evaluate clinical efficacy and safety of local Pingyangmycin injection combinedwith oral propranolol for the treatment of paediatric refractory hemangioma andascular malformations.MethodsA total of38cases were admitted into in our department in June2011to June2012.After clinical and ultrasound evaluations, all cases were given tumor injection withmixture of Pingyangmycin and dexamethasone under general anesthesia. If the firstinjection was invalid, repeated injection would be performed after interval of6weeks.once healed six weeks after the interval of repeated injections treatment each time theamount of Pingyangmycin not more than8mg，Not more than1mg per kg of bodyweight; propranolol next day1mg/kg morning10:00Dayton clothing, one hour aftertreatment,3hours,6hours of monitoring heart rate, after six hours every6hours ofmonitoring heart rate. Then propranolol was applied for1week in hospital and3to6months after discharge. Propranolol treatment was continued and all cases wererequired to return to clinic per half a month. Follow up time was3to8months. ResultsAfter comprehensive examination, all patients received drug injection at the tumor.Hemangioma color and texture were displayed within24hours after injection. After2months treatment, ultrasound examination implied that the average maximumthickness of the tumor reduced66.7%. No adverse effects were recorded in all thecases. According to Achauer grading system, there were1case of grade I (2.6%),9cases of grade II (23.7%),21cases of grade III (55.3%) and9cases of grade IV(18.4%).ConclusionLocal Pingyangmycin injection combined with oral propranolol was effective for thetreatment of paediatric refractory hemangioma. Most vascular malformationsremission or even cure.The method can shorten the natural process of the tumor andthe traumas were small, the adverse effects were light. Therefore, it could be regardedas a preferred management for infant refractory hemangioma and vascularmalformations with rapid growth feature. |
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