Research Of Metal-organic Frameworks As Chemical Sensors And Drug Delivery Of Docetaxel

MOFs (Metal Organic Frameworks, referred MOFs) are a class of hybridmaterials with unique porous structure, MOF is open pores of a permanent crystallinematrix, made of an organic ligand and a metal ion or metal clusters by complexation[1-3], they are also commonly referred as Porous Coordination Polymers (PCPs).Preparation of MOFs is simple, it has a high specific surface area (up to6x103m2/g)and ultra high porosity (up to90%free volume). MOFs show significant potentialapplications in the gas adsorption and separation, biomedicine, catalytic, chemicalsensor and so on.In this dissertation, two four-carboxylic acid ligand (H4TBAPy and H4TDBAPy)and a dicarboxylic acid ligands containing NH2group were used throughsolvothermal reaction leading to several microporous metal organic frameworksmaterials. Analysis methods such as X-ray diffraction, thermal gravimetric, gas andvapor adsorption were carried out to study the structures and properties of thesecompounds. Moreover, it was studied as a drug carrier by structural modifying.First, Zn2(TBAPy)bpy (MOF1) was synthesized by1,3,6,8-tetrakis(p-benzoicacid)pyrene (H4TBAPy),4,4’-bipyridine pyridine and zinc nitrate as a microporousfluorescent3D MOF. MOF1was a3D3-fold IPN (Interpenetrating PolymerNetwork), the compound had high thermal and chemical stability, it could be stableup to250°C and keep the structural integrity of framework in the presence ofdifferent organic solutions. In addition, MOF1showed fluorescence quenchingphenomenon in the presence of nitrobenzene, the fluorescence quenching was up to89.3%. The results showed that MOF1has potential applications in chemical sensor.Zr6O4(OH)4(TDBAPy)3(MOF2) was was synthesized by1,3,6,8-tetrakis(4’-carboxy[1,1’-biphenyl]-4-yl-)pyrene (H4TDBAPy) and zirconiumits Synthesis of fluorescent, as a microporous fluorescent3D MOF. MOF2had a highsurface area (3540.5m2g-1), excellent thermal stability (up to500°C) and prominentfluorescence. Furthermore, MOF2can adsorbed benzene and toluene quickly and efficiently, benzene adsorption capacity was up to17.5mmol/g, it was several timesas much as the conventional adsorbents. Finally, the fluorescent properties wereinvestigated and the result showed that fluorescence quenching in the presence ofnitrobenzene, the fluorescence intensity decreased68%in a very low nitrobenzenecontent of0.1vol%. MOF2had specifically recognize potential application in theadsorption of benzene and toluene，selective detection of nitrobenzene.The synthesis method of MIL-101(Fe) was explored and particle size was297.7nm using microwave method. FA-MIL-101-(Fe) was synthesized by structuralmodifying. FA-MIL-101-(Fe) was used for anticancer drug docetaxel, the docetaxelencapsulation efficiency was42.3%, docetaxel release from FA-MIL-101-(Fe) was64.15%at72h. MCF-7cells results show, there was no significant difference ofinhibition rate between Docetaxel loaded by FA-MIL-101-(Fe) system and pureDocetaxel, FA-MIL-101-(Fe) could successful load and release docetaxel for thetreatment.