| Objective1.To evaluation and analysis patient’s general information, the cognitive functionscore and sleep monitoring indicators in elderly patients with obstructive sleep apneahypopnea syndrom(OSAHS), and explore hypoxemia during sleep and the sleepstructure on the influence of cognitive function in elderly patients with OSAHS;2.Observe before and after nasal continuous positive airway pressure treatmentin elderly patients with obstructive sleep apnea hypopnea syndrom changes incognitive function.To evaluate the curative effect of nasal continuous positive airwaypressure treatment in elderly patients with OSAHS and cognitive impairmentMethodsCollected90elderly OSAHS patients in respiratory sleep department of theFirst affiliated hospital of Zhengzhou University from October2012to Otober2012(OSAHS group),Of which61males and29females, aged60-87years, mean (68±5)years old; Over the same period, collected30healthy subjects as controls, whichinvolved30healthy volunteers,18male cases and12female cases, the two groups BMI and generally conditions were all matched;Polysomnography(PSG)including apnea and hypopnea index(AHI), the lowest arterial oxygen saturation(LaSO2), sleep stage I to III and rapid eye movement sleep prorotion of total sleeptime,use the Montreal Cognitive Assessment (MoCA) to assess cognitive functionand use the Epworth sleepiness scale to evaluate daytime sleepiness.OSAHS groupon the basis of AHI into mild,moderate and severe groups.The treatment groupinvolved30OSAHS patients with cognitive dysfunction,Review the relatedindicators after3months of treatment.ResultsMild, moderate and severe OSAHS group than in the control group: AHI,ESSscore and (I+II)%were elevated(P＜0.01或P＜0.05)，LSaO2, III%, REM%decreased（P＜0.05），in OSAHS subgroups, with the sicker AHI,(I+II)%and ESSscores were higher, III%, REM%, LSaO2and MoCA score lower; AHI, LSaO2groupdifferences between subgroups in both OSAHS there was statistically significant（P＜0.05）.In terms of cognitive function and sleepiness, Comparison between OSAHSsubgroups Only severe OSAHS group with mild ESS score and MoCA score OSAHSgroup differences were statistically significant（P＜0.05）.OSAHS patients MoCAscore and LSaO2,REM%were positive correlation,(rLSaO2=0.562,P＜0.05;rREM%=0.498,P<0.05), OSAHS negatively correlate with AHI(r=-0.691,P<0.01);In cognitivefunction scores in each subgroup, visual spatial attention, naming, calculation,abstract thinking and memory was negatively correlated with AHI(Rvisual space=-0.322,P＜0.05; rnote=-0.255, P＜0.05;rname=-0.334,P＜0.05; rcalculated=-0.257,P＜0.05; rabstract thinking=-0.164, P＜0.05;rmemory=-0.380, P <0.05);Visual space,attention, naming, calculation, language, memory and LSaO2all have positivecorrelation(Rvisual space=0.513,P＜0.05; rattention=0.480,P＜0.05; rname=0.377, P＜0.05;rcalculated=0.245, P＜0.05;rlanguage=0.147, P＜0.05;rmemory=0.170, P <0.05)；Visual space, memory and III%naming have positive correlation (rvisual space=0.194,P＜0.05;rname=0.255, P＜0.05;rmemory=0.172, P <0.05).2.And cognitivedysfunction in OSAHS patients, after three months of comprehensive treatment, LSaO2, MoCA score, II%and REM%were increased,AHI,(I+II)%and ESS scoreswere statistically reduced (P <0.05), but in the MoCA scores in each group table,just pay attention, memory and computational aspects between before and aftertreatment were statistically significant differences between the groups (P <0.05).Conclusions1.Elderly OSAHS patients with sleep disordered structure, decreased sleepefficiency, and closely related to the severity of the disease.2. Elderly OSAHS patients are often have cognitive dysfunction.but mainly inmemory, calculation and focus areas, and the more severe the disease, the moresignificant cognitive impairment.3.nCPAP therapy may improve cognitive dysfunction in elderly patients withOSAHS on some extent, mainly in memory, calculating ability and attention aspects.Now memory, attention aspects of the computer, and the more severe the disease, themore significant cognitive impairment... |
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