The Clinical Observation Of The Application Of The Medical Ozone For The Treatment Of Chronic Nonhealing Wounds

Objective:1. To evaluate the role of medical ozone therapy in the management of thechronic nonhealing wounds.2. To provide a new idea for the mechanism study of the chronic nonhealingwounds healing and for the clinical treatment in the future．Materials and Methods:1. Materials21cases suffered from the chronic nonhealing wounds were collected, from theHospital of Shenyang General Military during March2012to March2014. All patients’wound surface had not a healing tendency for more than a month, and presented to theOzone Therapy Unit.5patients (23.81%) were venous ulcer and sixteen patients(76.19%) with diabetes mellitus,13of these (61.90%) with IDDM (insulin dependentdiabetes mellitus) and3(14.29%) with NIDDM (non insulin dependent). The mean agewas55.95±11.25years (33-75years).The gender distribution was14males (66.67%)and7females(33.33%), with a ratio of2:1. One patient (4.76%) was threatened byamputation.2. MethodsAll patients underwent accurate diagnosis and classification of the wound. Aftersuccessful management of diet and blood glucose, correction of underlying cause andmalnutrition, lower blood pressure and lipid, improvement of blood circulation,treatment of infection, taken wound secretions for bacterial culture and sensitivity test,debridement of necrotic tissues and underlying osteomyelitis, obliteration of dead space,if necessary, cut and open the tissue, relieve the compression of nerves and blood vessels of lower extremity. Finally, the medical ozone therapy was put into practiced.Treatment can be carried out on a daily basis. In the present study, ozone therapyprotocols were principally designed including administer ozonized water, ozonebagging, ozonized scream, and large autologous blood ozone therapy(LABOT). Thetreatment period was continuous67days for a stage，with interval of46days. Eachpatient had totally810stages. Patients were classified in three groups according tooutcome:(1) Cure-complete healing of the wound;(2) Marked improvement-morethan50%of the wound is healed;(3) Unsuccessful-less than50%of the wound ishealed and/or the condition of the patient or the wound requires surgical intervention.ResultsAfter ozone therapy, positive results were achieved in18patients (85.71%),11(52.38%) of them with complete healing and7(33.33%) of them with markedimprovement. Negative results were recorded in3patients (14.29%), in whom ozonetherapy failed to achieve any topical clinical effects. A striking result was that,1patient(4.76%) threatened by amputation, had been saved from amputation of the limb.None patients have adverse reaction.Conclusion1. Ozone therapy, as a new adjuvant modality in treatment of chronic nonhealingwounds, such as diabetic foot problems and other wounds, show a therapeutic effect,worthwhile clinical application;2. By cooperation application between local ozone therapy(ozonized water, ozonebagging, ozonized scream) and systemic ozone therapy (LABOT), the maximum effectcan be achieved.