The Value Of Detecting Blood Flow Of Renal Artery By Color Doppler Echocardiography In The Diagnosis Of Diabetic Nephropathy

Objective: The morbidity rate of DM, as a common and frequently-occurring disease,is increasing obviously with the improvement of people’s life, population aging andchanges of life style. And DM has been the most severe one among the chronicdiseases in the world. All kinds of acute or chronic complications are the majorreasons, resulting in diabetic damage. DN as the most common complication,reflecting the diabetic microangiopathy in kidney, is the main cause, leading toterminal renal failure. The absence of effect treatment in DN causes the diseasedeveloping progressively and coming to uremia at last. Therefore, early determinationand prevention is quite significant. The aim of this research was to provide valuedinspection methods of early diagnosis of DN via comparative analysis of RI amongnormal people, diabetic and non-diabetic patients.Methods: Using GE LOGIG7and ALOKA alpha10color Doppler ultrasonicdiagnostic instrument, frequency of2.5~2.5MHz probes color Doppler spectrumdetermination. When the renal artery color Doppler signals displayed clearly, thedoctor told patients to hold the breath and measured the blood flow parameters aboutcoronal plane of renal artery, segment renal artery and interlobar artery, and calculatedthe resistance index (RI).Normal control group: health people without previoushistory,16cases; Non-diabetic group: non-diabetic patients with previoushistory(hypertension, fatty liver, coronary heart disease),21cases; Diabetic group:patients with type two diabetes diagnosed according to temporary diabetic diagnosisstandard of WHO,23cases; Among these,12cases with the disease period1-5years,and11cases with disease period6-20years. Determine the renal artery blood flow of diabetic patients before and after treatment.Result:1. RI of Diabetic group before the treatment had a significant differencecompared with Normal control group（p<0.05）, and had no obvious differencecompared with non-diabetic group(hypertension, fatty liver, coronary heart disease).RI of Diabetic group after the treatment declined, but not obviously.2. The relative analysis between RI of DN patients and diabetic period indicatedthat RI of patients with diabetes over6years before and after treatment wassignificantly higher than RI of patients with diabetes less5years before and aftertreatment.3. The relative analysis between RI of intra-renal artery and age in the diabeticpatients indicated that RI of recently diagnosed diabetic patients with elder age beforetreatment was significantly higher than the lower age group. RIs between the elderage group and lower age group after treatment of lowing blood glucose declinedparallely and they still had the significant difference.Conclusion:1. RI of diabetic patients is significantly higher than Normal control group, andthis can be one of the standards of DN diagnosis, and reducing blood glucose canpartly improve the high resistance of renal artery.2. RI can reflect hemodynamic states of vessels in different phases of DN, andis positively correlated with the development of DN.3. RI of intra-renal artery in diabetic patients is positively correlated with theage of diagnosing diabetes.